Next Article in Journal
IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing
Next Article in Special Issue
Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia
Previous Article in Journal
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer
Previous Article in Special Issue
Targeting Apoptotic Pathways in Acute Myeloid Leukaemia
Article

The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia

1
Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
2
Department of Pediatric Hematology and Oncology, Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
3
Research Institute Children’s Cancer Center Hamburg, 20246 Hamburg, Germany
4
Center for Experimental Medicine, Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
5
Department of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
6
Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, 20246 Hannover, Germany
*
Author to whom correspondence should be addressed.
Received: 29 September 2019 / Revised: 24 October 2019 / Accepted: 25 October 2019 / Published: 26 October 2019
(This article belongs to the Special Issue Acute Myeloid Leukemia)
Leukemia-initiating cells reside within the bone marrow in specialized niches where they undergo complex interactions with their surrounding stromal cells. We have identified the actin-binding protein Plastin-3 (PLS3) as potential player within the leukemic bone marrow niche and investigated its functional role in acute myeloid leukemia. High expression of PLS3 was associated with a poor overall and event-free survival for AML patients. These findings were supported by functional in vitro and in vivo experiments. AML cells with a PLS3 knockdown showed significantly reduced colony numbers in vitro while the PLS3 overexpression variants resulted in significantly enhanced colony numbers compared to their respective controls. Furthermore, the survival of NSG mice transplanted with the PLS3 knockdown cells showed a significantly prolonged survival in comparison to mice transplanted with the control AML cells. Further studies should focus on the underlying leukemia-promoting mechanisms and investigate PLS3 as therapeutic target. View Full-Text
Keywords: Acute myeloid leukemia; Plastin-3; prognostic marker Acute myeloid leukemia; Plastin-3; prognostic marker
Show Figures

Figure 1

MDPI and ACS Style

Velthaus, A.; Cornils, K.; Hennigs, J.K.; Grüb, S.; Stamm, H.; Wicklein, D.; Bokemeyer, C.; Heuser, M.; Windhorst, S.; Fiedler, W.; Wellbrock, J. The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia. Cancers 2019, 11, 1663. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers11111663

AMA Style

Velthaus A, Cornils K, Hennigs JK, Grüb S, Stamm H, Wicklein D, Bokemeyer C, Heuser M, Windhorst S, Fiedler W, Wellbrock J. The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia. Cancers. 2019; 11(11):1663. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers11111663

Chicago/Turabian Style

Velthaus, Arne, Kerstin Cornils, Jan K. Hennigs, Saskia Grüb, Hauke Stamm, Daniel Wicklein, Carsten Bokemeyer, Michael Heuser, Sabine Windhorst, Walter Fiedler, and Jasmin Wellbrock. 2019. "The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia" Cancers 11, no. 11: 1663. https://0-doi-org.brum.beds.ac.uk/10.3390/cancers11111663

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop