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Interplay of Nanoparticle Properties during Endocytosis

by 1,2, 1,*, 1,*, 1,2 and 1,2
State Key Laboratory of Nonlinear Mechanics and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China
School of Engineering Science, University of Chinese Academy of Sciences, Beijing 100049, China
Authors to whom correspondence should be addressed.
Academic Editor: Rajratan Basu
Received: 30 May 2021 / Revised: 11 June 2021 / Accepted: 21 June 2021 / Published: 24 June 2021
Nanoparticles (NPs) have been widely applied as drug carriers in drug delivery, due to their unique physical and structural properties. To achieve the drug delivery purpose, receptor-mediated endocytosis is a primary explored mechanism to internalize NPs into tumor cells. During the endocytosis process, properties of NPs, including size, shape, and surface functionality, play an important role in determining the final drug delivery efficacy. Many of these NP properties have been extensively explored individually. However, the multiple NP properties naturally interplay with each other in the endocytosis process to determine the internalization efficiency together. Therefore, it is significantly important to understand the interplay of different NP properties to improve the NP’s final delivery efficacy. In this review, we focus on the interplay of NPs properties on the endocytosis process to summarize the relevant experimental observations and physical mechanisms. Particularly, three different aspects are discussed in detail, including the interplay between size and shape; size and elasticity; shape and elasticity. We have summarized the most recent works and highlighted that building up systematic understandings for the complex interplay between NP properties can greatly help a better design of NP platforms for drug delivery. View Full-Text
Keywords: nanoparticle; endocytosis; nanoparticle properties nanoparticle; endocytosis; nanoparticle properties
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MDPI and ACS Style

Wang, X.; Li, L.; Li, L.; Song, F.; Song, F. Interplay of Nanoparticle Properties during Endocytosis. Crystals 2021, 11, 728.

AMA Style

Wang X, Li L, Li L, Song F, Song F. Interplay of Nanoparticle Properties during Endocytosis. Crystals. 2021; 11(7):728.

Chicago/Turabian Style

Wang, Xiaohuan, Long Li, Long Li, Fan Song, and Fan Song. 2021. "Interplay of Nanoparticle Properties during Endocytosis" Crystals 11, no. 7: 728.

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