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Article

CKM Gene rs8111989 Polymorphism and Power Athlete Status

1
Department of Human and Medical Genetics, Institute of Biomedical Science, Faculty of Medicine, Vilnius University, 01513 Vilnius, Lithuania
2
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 5AF, UK
3
Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia
4
Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, 420010 Kazan, Russia
5
Department of Physical Education, Plekhanov Russian University of Economics, 115093 Moscow, Russia
6
Laboratory of Molecular Genetics, Kazan State Medical University, 420012 Kazan, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Juan Del Coso
Received: 21 August 2021 / Revised: 23 September 2021 / Accepted: 23 September 2021 / Published: 25 September 2021
(This article belongs to the Special Issue Genetics and Genomics in Sport)
Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success. View Full-Text
Keywords: anaerobic performance; creatine kinase; genetic variant; genotype anaerobic performance; creatine kinase; genetic variant; genotype
MDPI and ACS Style

Ginevičienė, V.; Jakaitienė, A.; Utkus, A.; Hall, E.C.R.; Semenova, E.A.; Andryushchenko, L.B.; Larin, A.K.; Moreland, E.; Generozov, E.V.; Ahmetov, I.I. CKM Gene rs8111989 Polymorphism and Power Athlete Status. Genes 2021, 12, 1499. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12101499

AMA Style

Ginevičienė V, Jakaitienė A, Utkus A, Hall ECR, Semenova EA, Andryushchenko LB, Larin AK, Moreland E, Generozov EV, Ahmetov II. CKM Gene rs8111989 Polymorphism and Power Athlete Status. Genes. 2021; 12(10):1499. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12101499

Chicago/Turabian Style

Ginevičienė, Valentina, Audronė Jakaitienė, Algirdas Utkus, Elliott C.R. Hall, Ekaterina A. Semenova, Liliya B. Andryushchenko, Andrey K. Larin, Ethan Moreland, Edward V. Generozov, and Ildus I. Ahmetov 2021. "CKM Gene rs8111989 Polymorphism and Power Athlete Status" Genes 12, no. 10: 1499. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12101499

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