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Article

Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis

1
Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
2
Sharjah Institute of Medical Research, University of Sharjah, Sharjah 27272, UAE
3
Obesity, Endocrine and Metabolic Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editors: Susanna Balcells Comas, Daniel Grinberg and Natalia Garcia-Giralt
Received: 20 December 2020 / Revised: 17 January 2021 / Accepted: 25 January 2021 / Published: 29 January 2021
(This article belongs to the Special Issue Genetic Disorders of Bone)
Receptor activator of the nuclear factor-κB ligand (RANKL) and osteoprotegerin genes (OPG) were identified as susceptible loci for postmenopausal osteoporosis (PMO) in various ethnicities, but neither have been studied in an Arabian population. Hence, the current study aimed to fill this gap. A total of 372 postmenopausal women (174 osteoporosis (OP) and 198 control group (CTRs)) were genotyped for four SNPs: rs2277438A/G and rs9533156T/C (RANKL), and rs2073618C/G and rs3102735T/C (OPG). Anthropometrics, bone mineral density, 25(OH)D and several other bone markers were measured. The frequency distribution of the heterozygous CG genotype of rs2073618 (OPG) was lower in the OP (36.8%) than in CTRs (47%) (OR: 0.6, 95% CI: 0.3–0.97; p = 0.041). No differences in the allelic/genotypic frequencies were detected between the two groups for all other studied SNPs. However, the heterozygous TC genotype of rs3102735 (OPG) was associated significantly with lower BMD at the femoral neck in OP subjects (p = 0.04). The homozygous rare CC genotype of rs9533156 (RANKL) was associated with lower 25(OH)D levels in CTRs (p = 0.032). In contrast, heterozygous AG genotype of rs2277438 (RANKL) is associated with lower 25(OH)D in the OP group (p = 0.02). Our results suggest that RANKL SNPs may impact 25(OH)D levels and that OPG SNP rs2073618A/G is a significant genetic risk factor for PMO Saudi Arabian women. View Full-Text
Keywords: RANKL/OPG; single nucleotide polymorphism; rs2277438; rs9533156; rs2073618; rs3102735; Saudi postmenopausal women RANKL/OPG; single nucleotide polymorphism; rs2277438; rs9533156; rs2073618; rs3102735; Saudi postmenopausal women
MDPI and ACS Style

Abdi, S.; Binbaz, R.A.; Mohammed, A.K.; Ansari, M.G.A.; Wani, K.; Amer, O.E.; Alnaami, A.M.; Aljohani, N.; Al-Daghri, N.M. Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis. Genes 2021, 12, 200. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12020200

AMA Style

Abdi S, Binbaz RA, Mohammed AK, Ansari MGA, Wani K, Amer OE, Alnaami AM, Aljohani N, Al-Daghri NM. Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis. Genes. 2021; 12(2):200. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12020200

Chicago/Turabian Style

Abdi, Saba, Rawan A. Binbaz, Abdul K. Mohammed, Mohammed G.A. Ansari, Kaiser Wani, Osama E. Amer, Abdullah M. Alnaami, Naji Aljohani, and Nasser M. Al-Daghri 2021. "Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis" Genes 12, no. 2: 200. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12020200

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