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Article

Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles

IFM Biology, Linköping University, 58186 Linköping, Sweden
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Author to whom correspondence should be addressed.
Academic Editors: Elaine Ostrander and Benjamin N. Sacks
Received: 28 January 2021 / Revised: 11 February 2021 / Accepted: 18 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Canine Genetics 2)
Loss of pigmentation is a hallmark of domestication, and dogs offer a unique model for understanding the genetics of fur coloration. The aim of this study was to use dense genetic mapping to map loci underlying variations in color and whiteness in a population of laboratory beagles. A total of 190 beagles with well-defined pedigrees were phenotyped for the amount of white color in six different body parts, including the saddle. All individuals were genotyped on 85,172 informative and valid SNP-markers and the genome-wide associations for the amount of white in each body part were determined. There was a large variation in the amount of white on different parts of the body, and the whiteness was highly correlated within individuals, except for saddle color which was only moderately correlated with overall whiteness. The GWAS showed significant associations with two loci, one on chromosome 5, containing the MC1R gene, and one on chromosome 20, containing the MITF gene. Our results suggest that the variation in loss of pigmentation is largely a function of regulatory variation related to these genes. View Full-Text
Keywords: dog; fur color; MITF; domestication dog; fur color; MITF; domestication
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MDPI and ACS Style

Nord, M.E.; Jensen, P. Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles. Genes 2021, 12, 316. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12020316

AMA Style

Nord ME, Jensen P. Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles. Genes. 2021; 12(2):316. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12020316

Chicago/Turabian Style

Nord, Mia E., and Per Jensen. 2021. "Genomic Regions Associated with Variation in Pigmentation Loss in Saddle Tan Beagles" Genes 12, no. 2: 316. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12020316

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