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The PARP Way to Epigenetic Changes

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Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
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Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
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Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA
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Beth Israel Deaconess Medical Center, Cancer Research Institute, Boston, MA 02215, USA
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Authors to whom correspondence should be addressed.
Academic Editor: Andrea Piunti
Received: 5 March 2021 / Revised: 15 March 2021 / Accepted: 17 March 2021 / Published: 20 March 2021
(This article belongs to the Special Issue Advances in Tumor Epigenetics Research)
ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from “nicotinamide adenine dinucleotide-donor molecules” to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond. View Full-Text
Keywords: genetics; epigenetics; gene regulation; PARP1; ADP-ribosyl transferases; PARylation genetics; epigenetics; gene regulation; PARP1; ADP-ribosyl transferases; PARylation
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MDPI and ACS Style

Ummarino, S.; Hausman, C.; Di Ruscio, A. The PARP Way to Epigenetic Changes. Genes 2021, 12, 446. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12030446

AMA Style

Ummarino S, Hausman C, Di Ruscio A. The PARP Way to Epigenetic Changes. Genes. 2021; 12(3):446. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12030446

Chicago/Turabian Style

Ummarino, Simone, Clinton Hausman, and Annalisa Di Ruscio. 2021. "The PARP Way to Epigenetic Changes" Genes 12, no. 3: 446. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12030446

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