Genes, Volume 12, Issue 4 (April 2021) – 149 articles
Cover Story (view full-size image): Ribosomes are macromolecular machines that perform protein synthesis in all living cells. The making of ribosomes—ribosome biogenesis—occurs largely in the nucleolus. Abnormal nucleoli have long since been used as a prognostic indicator for cancer. More recently, aberrant ribosome biogenesis has been observed in a host of different cancers, including breast cancer. Excitingly, the first step in ribosome biogenesis, the transcription of the rRNA, was identified as a therapeutic target to treat cancer. Two new drugs that target rRNA synthesis were tested in humans, one of which has recently expanded its clinical trial to include breast cancers with abnormal BRCA1/2, with more possibilities being discovered. View this paper
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