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Article

Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population

1
Research Center in Policies, Population and Health, School of Medicine, National Autonomous University of Mexico (UNAM), Mexico 04510, Mexico
2
Department of Genetics, National Institute of Rehabilitation (INR), Mexico 014389, Mexico
3
Genomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico 14610, Mexico
4
Laboratory of Genomics of Cardiovascular Diseases, National Institute of Genomic Medicine (INMEGEN), Mexico 14610, Mexico
5
Epidemiological and Health Services Research Unit, Morelos Delegation, Mexican Institute of Social Security, Cuernavaca, Morelos 62000, Mexico
6
University of California, Los Angeles (UCLA), Department of Health Policy and Management and UCLA-Kaiser Permanente Center for Health Equity, Fielding School of Public Health, Los Angeles, CA 90095, USA
7
UCLA Center for Cancer Prevention and Control Research, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Current Address: Infection Disease Division, Department of Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada
Academic Editor: Zhousheng Xiao
Received: 29 June 2021 / Revised: 27 July 2021 / Accepted: 27 July 2021 / Published: 29 July 2021
(This article belongs to the Special Issue Genetic Disorders of Bone)
Vitamin D-binding protein (VDBP) is encoded by the GC gene and is an active participant in the control of bone metabolism. However, the effect of its major variants on VDBP concentration and bone mineral density (BMD) remains unclear. Our aim was to analyze the effect of major GC variants on serum VDBP concentration and BMD. We recruited individuals from the Health Workers Cohort Study, which includes employees of the Mexican Institute of Social Security (IMSS). A total of 1853 adults were included. The single nucleotide polymorphisms (SNPs) rs7041 and rs4588 were genotyped to identify the three best characterized haplotypes of GC. Serum VBDP, 25(OH)D and BMD were also measured. Among women, the G allele of rs7041 was associated with higher VDBP and BMD compared to homozygous TT. The A allele of rs4588 was associated with lower VDBP and BMD compared to CC homozygous. In men, GC variants were only associated with VDBP levels. We did not observe an association between free/bioavailable 25(OH)D and BMD in men and women. Our results support an association of VDBP in bone health. The G and C alleles, from rs7041 and rs4588, respectively, are associated with high concentrations of VDBP and BMD in this sample of Mexican postmenopausal women. View Full-Text
Keywords: GC gene; vitamin D binding protein; bone mineral density; Mexican population; sex GC gene; vitamin D binding protein; bone mineral density; Mexican population; sex
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MDPI and ACS Style

Rivera-Paredez, B.; Hidalgo-Bravo, A.; León-Reyes, G.; Antuna-Puente, B.; Flores, Y.N.; Salmerón, J.; Velázquez-Cruz, R. Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population. Genes 2021, 12, 1176. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12081176

AMA Style

Rivera-Paredez B, Hidalgo-Bravo A, León-Reyes G, Antuna-Puente B, Flores YN, Salmerón J, Velázquez-Cruz R. Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population. Genes. 2021; 12(8):1176. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12081176

Chicago/Turabian Style

Rivera-Paredez, Berenice, Alberto Hidalgo-Bravo, Guadalupe León-Reyes, Bárbara Antuna-Puente, Yvonne N. Flores, Jorge Salmerón, and Rafael Velázquez-Cruz. 2021. "Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population" Genes 12, no. 8: 1176. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12081176

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