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Genetic Markers of Differential Vulnerability to Sleep Loss in Adults

Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, 1645 W. Jackson Blvd., Suite 425, Chicago, IL 60612, USA
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Academic Editors: Jonathan Wisor and Brieann Satterfield
Received: 17 July 2021 / Revised: 18 August 2021 / Accepted: 24 August 2021 / Published: 26 August 2021
(This article belongs to the Special Issue Genetics of Sleep, Sleep Loss, and Cognitive Impairment)
In this review, we discuss reports of genotype-dependent interindividual differences in phenotypic neurobehavioral responses to total sleep deprivation or sleep restriction. We highlight the importance of using the candidate gene approach to further elucidate differential resilience and vulnerability to sleep deprivation in humans, although we acknowledge that other omics techniques and genome-wide association studies can also offer insights into biomarkers of such vulnerability. Specifically, we discuss polymorphisms in adenosinergic genes (ADA and ADORA2A), core circadian clock genes (BHLHE41/DEC2 and PER3), genes related to cognitive development and functioning (BDNF and COMT), dopaminergic genes (DRD2 and DAT), and immune and clearance genes (AQP4, DQB1*0602, and TNFα) as potential genetic indicators of differential vulnerability to deficits induced by sleep loss. Additionally, we review the efficacy of several countermeasures for the neurobehavioral impairments induced by sleep loss, including banking sleep, recovery sleep, caffeine, and naps. The discovery of reliable, novel genetic markers of differential vulnerability to sleep loss has critical implications for future research involving predictors, countermeasures, and treatments in the field of sleep and circadian science. View Full-Text
Keywords: total sleep deprivation; sleep restriction; candidate genes; polymorphisms; circadian clock genes; interindividual differences; vulnerability; resilience; neurobehavioral; countermeasures total sleep deprivation; sleep restriction; candidate genes; polymorphisms; circadian clock genes; interindividual differences; vulnerability; resilience; neurobehavioral; countermeasures
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MDPI and ACS Style

Casale, C.E.; Goel, N. Genetic Markers of Differential Vulnerability to Sleep Loss in Adults. Genes 2021, 12, 1317. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12091317

AMA Style

Casale CE, Goel N. Genetic Markers of Differential Vulnerability to Sleep Loss in Adults. Genes. 2021; 12(9):1317. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12091317

Chicago/Turabian Style

Casale, Courtney E., and Namni Goel. 2021. "Genetic Markers of Differential Vulnerability to Sleep Loss in Adults" Genes 12, no. 9: 1317. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12091317

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