Next Article in Journal
The Silencing of a 14-3-3ɛ Homolog in Tenebrio molitor Leads to Increased Antimicrobial Activity in Hemocyte and Reduces Larval Survivability
Previous Article in Journal
Remodeling and Control of Homologous Recombination by DNA Helicases and Translocases that Target Recombinases and Synapsis
Article

Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese

by 1,†, 2,†, 2,†, 2 and 2,*
1
Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China
2
Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Josyf C. Mychaleckyj
Received: 2 June 2016 / Revised: 31 July 2016 / Accepted: 11 August 2016 / Published: 20 August 2016
(This article belongs to the Section Human Genomics and Genetic Diseases)
Retinoic acid receptor-related orphan receptor alpha (RORA) plays a key role in the regulation of lipid and glucose metabolism and insulin expression that are implicated in the development of type 2 diabetes mellitus (T2DM). However, the effects of genetic variants in the RORA gene on the susceptibility to T2DM remain unknown. Nine tagging single-nucleotide polymorphisms (SNPs) were screened by using the SNaPshot method in 427 patients with T2DM and 408 normal controls. Association between genotypes and haplotypes derived from these SNPs with T2DM was analyzed using different genetic models. Allele and genotype frequencies at rs10851685 were significantly different between T2DM patients and control subjects (allele: p = 0.009, Odds ratios (OR) = 1.36 [95% Confidence intervals (CI) = 1.08–1.72]; genotype: p = 0.029). The minor allele T, at rs10851685, was potentially associated with an increased risk of T2DM in the dominant model, displaying OR of 1.38 (95% CI: 1.04–1.82, p = 0.025) in subjects with genotypes TA+TT vs. AA. In haplotype analysis, we observed that haplotypes GGTGTAACT, GGTGTAACC, and GATATAACT were significantly associated with increased risk of T2DM, while haplotypes GATGAAGTT, AGTGAAGTT, and AATGAAATT were protective against T2DM. These data suggest that the genetic variation in RORA might determine a Chinese Han individual’s susceptibility to T2DM. View Full-Text
Keywords: RORA; type 2 diabetes; gene variation; association; haplotype RORA; type 2 diabetes; gene variation; association; haplotype
Show Figures

Figure 1

  • Supplementary File 1:

    PDF-Document (PDF, 195 KiB)

  • Externally hosted supplementary file 1
    Link: http://no
    Description: Nine SNPs in the RORA gene in the study
MDPI and ACS Style

Zhang, Y.; Liu, Y.; Liu, Y.; Zhang, Y.; Su, Z. Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese. Genes 2016, 7, 54. https://0-doi-org.brum.beds.ac.uk/10.3390/genes7080054

AMA Style

Zhang Y, Liu Y, Liu Y, Zhang Y, Su Z. Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese. Genes. 2016; 7(8):54. https://0-doi-org.brum.beds.ac.uk/10.3390/genes7080054

Chicago/Turabian Style

Zhang, Yuwei, Yulan Liu, Yin Liu, Yanjie Zhang, and Zhiguang Su. 2016. "Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese" Genes 7, no. 8: 54. https://0-doi-org.brum.beds.ac.uk/10.3390/genes7080054

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop