Genes, Volume 8, Issue 9 (September 2017) – 27 articles
Cover Story (view full-size image): Zebrafish are an emerging model for cancer research, enabling high-resolution in vivo imaging. Using xenotransplantation of fluorescent glioma cells, we validated the effect of silencing RECQ1 helicase, an enzyme involved in DNA repair and upregulated in some brain tumours, on tumour progression in zebrafish embryos. Measurements of tumour growth in the zebrafish brain confirmed the effects of RECQ1 helicase silencing in experiments in vitro. These results may help improve glioma treatment by targeting DNA-repair in tumour cells. View this paper
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