Antibodies, Volume 9, Issue 4 (December 2020) – 22 articles
Cover Story (view full-size image): Recent years have seen great advances in our understanding of the mechanisms of action of anticancer antibodies. In particular, the importance of the antibody Fc region has become clear; leading to an array of new strategies to engineer antibodies with enhanced activity. Techniques such as mutagenesis and glycoengineering have been employed to manipulate interactions between antibody Fc and Fc gamma receptors, complements, and the neonatal Fc receptor, leading to altered function. With the rules of engagement depending on antibody target and context, having a large toolkit of engineering options allows for a modular ‘plug and play’ approach to effective drug development. These engineered antibodies are arriving in the clinic in growing numbers and are beginning to deliver patient benefits. View this paper
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