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Review

Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations

1
Cancer Metastasis Laboratory, Department of Biomedicine, University of Basel and University Hospital Basel, 4058 Basel, Switzerland
2
Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
3
Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland
4
Hepatology Laboratory, Department of Biomedicine, University of Basel and University Hospital Basel, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Received: 15 April 2018 / Revised: 4 May 2018 / Accepted: 7 May 2018 / Published: 9 May 2018
(This article belongs to the Special Issue Circulating Tumor Cells as Cancer Diagnostic Biomarkers)
The field of cancer diagnostics has recently been impacted by new and exciting developments in the area of liquid biopsy. A liquid biopsy is a minimally invasive alternative to surgical biopsies of solid tissues, typically achieved through the withdrawal of a blood sample or other body fluids, allowing the interrogation of tumor-derived material including circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) fragments that are present at a given time point. In this short review, we discuss a few studies that summarize the state-of-the-art in the liquid biopsy field from a diagnostic perspective, and speculate on current challenges and expectations of implementing liquid biopsy testing for cancer diagnosis and monitoring in the clinical setting. View Full-Text
Keywords: circulating tumor cells; single cell analysis; deep-sequencing; liquid biopsy; cancer diagnosis; cancer treatment circulating tumor cells; single cell analysis; deep-sequencing; liquid biopsy; cancer diagnosis; cancer treatment
MDPI and ACS Style

Castro-Giner, F.; Gkountela, S.; Donato, C.; Alborelli, I.; Quagliata, L.; Ng, C.K.Y.; Piscuoglio, S.; Aceto, N. Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations. Diagnostics 2018, 8, 31. https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics8020031

AMA Style

Castro-Giner F, Gkountela S, Donato C, Alborelli I, Quagliata L, Ng CKY, Piscuoglio S, Aceto N. Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations. Diagnostics. 2018; 8(2):31. https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics8020031

Chicago/Turabian Style

Castro-Giner, Francesc, Sofia Gkountela, Cinzia Donato, Ilaria Alborelli, Luca Quagliata, Charlotte K.Y. Ng, Salvatore Piscuoglio, and Nicola Aceto. 2018. "Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations" Diagnostics 8, no. 2: 31. https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics8020031

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