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Open AccessEditorial

New Aspects of the Epigenetics of Pancreatic Carcinogenesis

1
Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Gastroenterology, Ankara University School of Medicine, School of Medicine, 06100 Ankara, Turkey
3
Departments of Paediatrics, Oncology, and Physiology and Pharmacology, University of Western Ontario, Children’s Health Research Institute, London, ON N6C 2V5, Canada
*
Author to whom correspondence should be addressed.
Received: 20 August 2020 / Accepted: 25 August 2020 / Published: 31 August 2020
(This article belongs to the Special Issue Epigenetics of Pancreatic Cancer 2.0)
Pancreatic cancer remains among the deadliest forms of cancer with a 5 year survival rate less than 10%. With increasing numbers being observed, there is an urgent need to elucidate the pathogenesis of pancreatic cancer. While both contribute to disease progression, neither genetic nor environmental factors completely explain susceptibility or pathogenesis. Defining the links between genetic and environmental events represents an opportunity to understand the pathogenesis of pancreatic cancer. Epigenetics, the study of mitotically heritable changes in genome function without a change in nucleotide sequence, is an emerging field of research in pancreatic cancer. The main epigenetic mechanisms include DNA methylation, histone modifications and RNA interference, all of which are altered by changes to the environment. Epigenetic mechanisms are being investigated to clarify the underlying pathogenesis of pancreatic cancer including an increasing number of studies examining the role as possible diagnostic and prognostic biomarkers. These mechanisms also provide targets for promising new therapeutic approaches for this devastating malignancy. View Full-Text
MDPI and ACS Style

Toruner, M.; Fernandez-Zapico, M.E.; Pin, C.L. New Aspects of the Epigenetics of Pancreatic Carcinogenesis. Epigenomes 2020, 4, 18. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes4030018

AMA Style

Toruner M, Fernandez-Zapico ME, Pin CL. New Aspects of the Epigenetics of Pancreatic Carcinogenesis. Epigenomes. 2020; 4(3):18. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes4030018

Chicago/Turabian Style

Toruner, Murat; Fernandez-Zapico, Martin E.; Pin, Christopher L. 2020. "New Aspects of the Epigenetics of Pancreatic Carcinogenesis" Epigenomes 4, no. 3: 18. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes4030018

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