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Open AccessFeature PaperReview

The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta

1
Department of Physiological Sciences, University of Florida, Gainesville, FL 32610-0144, USA
2
Grupo de Investigación en Génetica, Mejoramiento y Modelación Animal-GaMMA, Universidad de Antioquia, Medellín 050010, Colombia
3
Bond Life Sciences Center, Department of Biomedical Sciences, Thompson Center for Autism and Neurobehavioral Disorders, Informatics Institute, and Genetics Area Program, University of Missouri, Columbia, MO 65211, USA
4
Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
*
Author to whom correspondence should be addressed.
Received: 1 July 2020 / Revised: 12 August 2020 / Accepted: 19 August 2020 / Published: 2 September 2020
(This article belongs to the Collection Histone Demethylases)
Epigenetic modifications regulate normal physiological, as well as pathological processes in various organs, including the uterus and placenta. Both organs undergo dramatic and rapid restructuring that depends upon precise orchestration of events. Epigenetic changes that alter transcription and translation of gene-sets regulate such responses. Histone modifications alter the chromatin structure, thereby affecting transcription factor access to gene promoter regions. Binding of histones to DNA is regulated by addition or removal of subunit methyl and other groups, which can inhibit or stimulate transcription. Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) and subsequently suppresses transcription of genes bound by such histones. Uterine EZH2 expression exerts a critical role in development and function of this organ with deletion of this gene resulting in uterine hyperplasia and expression of cancer-associated transcripts. Elucidating the roles of EZH2 in uterus and placenta is essential as EZH2 dysregulation is associated with several uterine and placental pathologies. Herein, we discuss EZH2 functions in uterus and placenta, emphasizing its physiological and pathological importance. View Full-Text
Keywords: epigenetics; endometrium; stroma; transgenic mice; endometrial cancer; trophoblast; disease epigenetics; endometrium; stroma; transgenic mice; endometrial cancer; trophoblast; disease
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MDPI and ACS Style

Mesa, A.M.; Rosenfeld, C.S.; Tuteja, G.; Medrano, T.I.; Cooke, P.S. The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta. Epigenomes 2020, 4, 20. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes4030020

AMA Style

Mesa AM, Rosenfeld CS, Tuteja G, Medrano TI, Cooke PS. The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta. Epigenomes. 2020; 4(3):20. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes4030020

Chicago/Turabian Style

Mesa, Ana M.; Rosenfeld, Cheryl S.; Tuteja, Geetu; Medrano, Theresa I.; Cooke, Paul S. 2020. "The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta" Epigenomes 4, no. 3: 20. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes4030020

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