Epigenomes, Volume 4, Issue 4 (December 2020) – 6 articles
Cover Story (view full-size image): Epigenomes modulate cell differentiation, maturation, and biological function, which also participate in cancer development. As a result of the epigenetic silencing of inflammatory-related genes, some tumors may not respond to immunotherapy. Moreover, tumor-associated cells also contribute to immune quiescence via epigenetic regulation. Hence, targeting specific cells with epigenetic inhibitors in combination with immunotherapy may be a potential therapeutic strategy. In this review, we summarize several clinical trials that combined epigenetic inhibitors with immunotherapy and the potential for epigenetic control of the tumor microenvironment to improve immunotherapy. View this paper
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