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UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review
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Epigenetic Regulation of Epidermal Differentiation

Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland
Received: 10 November 2020 / Revised: 19 December 2020 / Accepted: 23 December 2020 / Published: 1 January 2021
(This article belongs to the Collection Epigenetic Regulation of Cellular Differentiation)
The epidermis is the outer part of the skin that protects the organism from dehydration and shields from external insults. Epidermal cells, called keratinocytes, undergo a series of morphological and metabolic changes that allow them to establish the biochemical and structural elements of an effective epidermal barrier. This process, known as epidermal differentiation, is critical for the maintenance of the epidermis under physiological conditions and also under stress or in various skin pathologies. Epidermal differentiation relies on a highly coordinated program of gene expression. Epigenetic mechanisms, which commonly include DNA methylation, covalent histone modifications, and microRNA (miRNA) activity, modulate various stages of gene expression by altering chromatin accessibility and mRNA stability. Their involvement in epidermal differentiation is a matter of intensive studies, and the results obtained thus far show a complex network of epigenetic factors, acting together with transcriptional regulators, to maintain epidermal homeostasis and counteract adverse effects of environmental stressors. View Full-Text
Keywords: epigenetic mechanisms; epidermal differentiation; DNA methylation; histone modifications; microRNAs; skin aging; skin diseases; wound healing epigenetic mechanisms; epidermal differentiation; DNA methylation; histone modifications; microRNAs; skin aging; skin diseases; wound healing
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MDPI and ACS Style

Leśniak, W. Epigenetic Regulation of Epidermal Differentiation. Epigenomes 2021, 5, 1. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes5010001

AMA Style

Leśniak W. Epigenetic Regulation of Epidermal Differentiation. Epigenomes. 2021; 5(1):1. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes5010001

Chicago/Turabian Style

Leśniak, Wiesława. 2021. "Epigenetic Regulation of Epidermal Differentiation" Epigenomes 5, no. 1: 1. https://0-doi-org.brum.beds.ac.uk/10.3390/epigenomes5010001

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