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Open AccessArticle

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

1
Department of Psychiatry, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, 6525 GA Nijmegen, The Netherlands
2
Department of Cognitive Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, 6525 EN Nijmegen, The Netherlands
3
Laboratory of Microbiology, Wageningen University, 6708 WE Wageningen, The Netherlands
4
Karakter Child and Adolescent Psychiatry University Center, 6525 GC Nijmegen, The Netherlands
5
Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, 6525 GA Nijmegen, The Netherlands
6
Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Authors contributed equally to this work.
Received: 5 February 2020 / Revised: 6 March 2020 / Accepted: 11 March 2020 / Published: 13 March 2020
(This article belongs to the Special Issue Microbiota-Gut-Brain Axis)
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Given the growing evidence of gut microbiota being involved in psychiatric (including neurodevelopmental) disorders, we aimed to identify differences in gut microbiota composition between participants with ADHD and controls and to investigate the role of the microbiota in inattention and hyperactivity/impulsivity. Fecal samples were collected from 107 participants (NADHD = 42; Ncontrols = 50; NsubthreholdADHD = 15; range age: 13–29 years). The relative quantification of bacterial taxa was done using 16S ribosomal RNA gene amplicon sequencing. Beta-diversity revealed significant differences in bacterial composition between participants with ADHD and healthy controls, which was also significant for inattention, but showing a trend in case of hyperactivity/impulsivity only. Ten genera showed nominal differences (p < 0.05) between both groups, of which seven genera were tested for their association with ADHD symptom scores (adjusting for age, sex, body mass index, time delay between feces collection and symptoms assessment, medication use, and family relatedness). Our results show that variation of a genus from the Ruminococcaceae family (Ruminococcaceae_UCG_004) is associated (after multiple testing correction) with inattention symptoms and support the potential role of gut microbiota in ADHD pathophysiology. View Full-Text
Keywords: gut microbiota; ADHD; 16S rRNA gene; Inattention gut microbiota; ADHD; 16S rRNA gene; Inattention
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MDPI and ACS Style

Szopinska-Tokov, J.; Dam, S.; Naaijen, J.; Konstanti, P.; Rommelse, N.; Belzer, C.; Buitelaar, J.; Franke, B.; Aarts, E.; Arias Vasquez, A. Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms. Microorganisms 2020, 8, 406. https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms8030406

AMA Style

Szopinska-Tokov J, Dam S, Naaijen J, Konstanti P, Rommelse N, Belzer C, Buitelaar J, Franke B, Aarts E, Arias Vasquez A. Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms. Microorganisms. 2020; 8(3):406. https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms8030406

Chicago/Turabian Style

Szopinska-Tokov, Joanna; Dam, Sarita; Naaijen, Jilly; Konstanti, Prokopis; Rommelse, Nanda; Belzer, Clara; Buitelaar, Jan; Franke, Barbara; Aarts, Esther; Arias Vasquez, Alejandro. 2020. "Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms" Microorganisms 8, no. 3: 406. https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms8030406

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