Med. Sci., Volume 8, Issue 4 (December 2020) – 11 articles
Cover Story (view full-size image): Extracellular vesicles (EVs) are lipid-bound nanoparticles generated by most cell types and can be isolated from many biological fluids. EVs are known to play a critical role in intercellular communication and inter-organ crosstalk through the delivery of their EV cargo, which is made up of a broad spectrum of molecules, including lipids, proteins, and nucleic acids. The composition of EV cargo is dependent on both the cell type and current pathophysiological status of the host cell. Although the mechanisms behind the production, secretion, and selective packaging of cargo in EVs remain somewhat misunderstood, recent evidence suggests that caveolin-1 regulates these processes in some EVs. In this article, we review the current understanding of this emerging and novel role of caveolin-1. View this paper.
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