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Acknowledgment to Reviewers of Medical Sciences in 2020
Review

Epidemiology of Non-Hodgkin’s Lymphoma

1
Department of Pulmonary and Critical Care Medicine, Sentara Virginia Beach General Hospital, Virginia Beach, VA 23455, USA
2
Sidney Kimmel Cancer Center, Jefferson University, Philadelphia, PA 19107, USA
3
Plains Regional Medical Group Internal Medicine, Clovis, NM 88101, USA
4
Department of Medicine, Nephrology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
5
Hematologist-Oncologist, Allegheny Health Network, Pittsburgh, PA 15212, USA
6
Department of Medicine, Sovah Health, Martinsville, VA 24112, USA
*
Author to whom correspondence should be addressed.
Received: 28 December 2020 / Revised: 26 January 2021 / Accepted: 27 January 2021 / Published: 30 January 2021
(This article belongs to the Section Cancer and Cancer-Related Research)
Non-Hodgins’s lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL accounts for 4% of US cancer diagnoses, and incidence has increased 168% since 1975 (while survival has improved 158%). NHL is more common among men, those >65 years old, and those with autoimmune disease or a family history of hematological malignancies. NHL is a heterogenous disease, with each subtype associated with different risk factors. Marginal zone lymphoma (MZL) is strongly associated with Sjogren’s syndrome (SS) and Hashimoto’s thyroiditis, while peripheral T-cell lymphoma (PTCL) is most associated with celiac disease. Occupational exposures among farm workers or painters increases the risk of most of the common subtypes. Prior radiation treatment, obesity, and smoking are most highly associated with diffuse large B-cell lymphoma (DLBCL), while breast implants have been rarely associated with anaplastic large cell lymphoma (ALCL). Infection with Epstein–Barr Virus (EBV) is strongly associated with endemic Burkitts lymphoma. HIV and human herpes virus 8 (HHV-8), is predisposed to several subtypes of DLBCL, and human T-cell lymphoma virus (HTLV-1) is a causative agent of T-cell lymphomas. Obesity and vitamin D deficiency worsen NHL survival. Atopic diseases and alcohol consumption seem to be protective against NHL. View Full-Text
Keywords: NHL; non-Hodgkin’s lymphoma; epidemiology; incidence; prevalence; mortality; prevention; risk factors NHL; non-Hodgkin’s lymphoma; epidemiology; incidence; prevalence; mortality; prevention; risk factors
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MDPI and ACS Style

Thandra, K.C.; Barsouk, A.; Saginala, K.; Padala, S.A.; Barsouk, A.; Rawla, P. Epidemiology of Non-Hodgkin’s Lymphoma. Med. Sci. 2021, 9, 5. https://0-doi-org.brum.beds.ac.uk/10.3390/medsci9010005

AMA Style

Thandra KC, Barsouk A, Saginala K, Padala SA, Barsouk A, Rawla P. Epidemiology of Non-Hodgkin’s Lymphoma. Medical Sciences. 2021; 9(1):5. https://0-doi-org.brum.beds.ac.uk/10.3390/medsci9010005

Chicago/Turabian Style

Thandra, Krishna C., Adam Barsouk, Kalyan Saginala, Sandeep A. Padala, Alexander Barsouk, and Prashanth Rawla. 2021. "Epidemiology of Non-Hodgkin’s Lymphoma" Medical Sciences 9, no. 1: 5. https://0-doi-org.brum.beds.ac.uk/10.3390/medsci9010005

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