Next Article in Journal
Genetic Investigation of Four Beluga Sturgeon (Huso huso, L.) Broodstocks for its Reintroduction in the Po River Basin
Next Article in Special Issue
Bisphenols and the Development of Type 2 Diabetes: The Role of the Skeletal Muscle and Adipose Tissue
Previous Article in Journal
Environmental Impacts of Conventional versus Organic Eggplant Cultivation Systems: Influence of Electricity Mix, Yield, Over-Fertilization, and Transportation
Article

Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants

1
School of Nutrition, Faculty of Agricultural and Food Sciences, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, Canada
2
Institute of Nutrition and Functional Foods, Université Laval, 2440 Boulevard Hochelaga, Quebec City, QC G1V 0A6, Canada
3
Centre de Recherche en Reproduction, Développement et Santé Intergénérationnelle, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, Canada
4
Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Université Laval, 2425 rue de l’Agriculture, Quebec City, QC G1V 0A6, Canada
5
Department of Medicine, Faculty of Medicine, Quebec Heart and Lung Institute Cardiology Group, Université Laval, 2725 Chemin Ste-Foy, Quebec City, QC G1V 4G5, Canada
6
Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, 3655 Promenade Sir William Osler Room 1325, Montreal, QC H3G 1Y6, Canada
7
Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, 21111 Lakeshore Road, Sainte Anne de Bellevue, QC H9X 3V9, Canada
8
Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre Research Institute, McGill University, 1001 Boulevard Décarie, Montreal, QC H4A 3J1, Canada
9
Nutrition Research Division, Health Canada, 251 Promenade Sir Frederick Banting, Ottawa, ON K1A 0K9, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Céline Aguer
Received: 6 February 2021 / Revised: 15 March 2021 / Accepted: 15 March 2021 / Published: 22 March 2021
(This article belongs to the Special Issue Effect of Environmental Pollutants on Metabolic Defects)
Exposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects glucose homeostasis and whether maternal FA supplementation counteracts POP effects transmitted via male descendants. Sprague–Dawley founder dams (F0) were fed a diet containing 2 or 6 mg/kg of FA and were force-fed with either a POP mixture or corn oil for 9 weeks. Subsequent male descendants did not receive any treatment. Blood glucose, plasma insulin and C-peptide were measured during an oral glucose tolerance test in males aged 90 and 180 days from generation 1 (F1), 2 (F2) and 3 (F3). Prenatal POP exposure increased fasting glucose in 90-day-old F1 males and C-peptide in 90-day-old F2 males. Prenatal FA supplementation decreased C-peptide in 90 and 180-day-old F1 males. In 180-day-old F3 males, FA supplementation counteracted POPs on fasting and postglucose C-peptide, indicating reduced insulin secretion. Prenatal exposure to an environmentally relevant POP mixture caused abnormalities in glucose homeostasis that are transmitted from one generation to the next through the paternal lineage. Prenatal FA supplementation counteracted some of the deleterious effects of POPs on glucose homeostasis. View Full-Text
Keywords: pollutants; folic acid; metabolic defects; insulin resistance; prenatal exposure; male lineage pollutants; folic acid; metabolic defects; insulin resistance; prenatal exposure; male lineage
Show Figures

Figure 1

MDPI and ACS Style

Navarro, P.; Dalvai, M.; L. Charest, P.; Herst, P.M.; Lessard, M.; Marcotte, B.; Leblanc, N.; Kimmins, S.; Trasler, J.; MacFarlane, A.J.; Marette, A.; L. Bailey, J.; Jacques, H. Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants. Environments 2021, 8, 24. https://0-doi-org.brum.beds.ac.uk/10.3390/environments8030024

AMA Style

Navarro P, Dalvai M, L. Charest P, Herst PM, Lessard M, Marcotte B, Leblanc N, Kimmins S, Trasler J, MacFarlane AJ, Marette A, L. Bailey J, Jacques H. Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants. Environments. 2021; 8(3):24. https://0-doi-org.brum.beds.ac.uk/10.3390/environments8030024

Chicago/Turabian Style

Navarro, Pauline, Mathieu Dalvai, Phanie L. Charest, Pauline M. Herst, Maryse Lessard, Bruno Marcotte, Nadine Leblanc, Sarah Kimmins, Jacquetta Trasler, Amanda J. MacFarlane, André Marette, Janice L. Bailey, and Hélène Jacques. 2021. "Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants" Environments 8, no. 3: 24. https://0-doi-org.brum.beds.ac.uk/10.3390/environments8030024

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop