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Review

Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota

1
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy
2
Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy
3
Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome, Italy
4
Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
These authors should be considered joint first author.
Received: 12 August 2020 / Revised: 26 August 2020 / Accepted: 28 August 2020 / Published: 29 August 2020
Osteoporosis (OP) is a bone disease consisting of a progressive loss of bone mineral density (BMD) and therefore resulting in greater susceptibility to fractures. OP shares a number of risk factors and demographic characteristics with periodontitis (PD), a bacteria-induced chronic inflammation of periodontal structures that leads to loss of alveolar bone and teeth. In the last decade, with the advent of gut and oral microbiome studies and profiling, a growing diagnostic and prognostic significance has been attributed to dysbiosis associated with various systemic and organ-specific pathologies. This evidence has inspired research on modulating the microbiota to restore health by the use of prebiotics and probiotics. The aim of this work is to overview the bidirectional interrelationships between OP and PD, reporting the most recent evidence on triggering factors and, mainly, the role of gut and oral dysbiosis in the onset and progression of both OP and PD, with the perspective in their therapy. View Full-Text
Keywords: osteoporosis; periodontitis; oral health; bone and bones/metabolism; microbiome; microbiota; prebiotics; probiotics; mouth diseases; osteology osteoporosis; periodontitis; oral health; bone and bones/metabolism; microbiome; microbiota; prebiotics; probiotics; mouth diseases; osteology
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MDPI and ACS Style

Contaldo, M.; Itro, A.; Lajolo, C.; Gioco, G.; Inchingolo, F.; Serpico, R. Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota. Appl. Sci. 2020, 10, 6000. https://0-doi-org.brum.beds.ac.uk/10.3390/app10176000

AMA Style

Contaldo M, Itro A, Lajolo C, Gioco G, Inchingolo F, Serpico R. Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota. Applied Sciences. 2020; 10(17):6000. https://0-doi-org.brum.beds.ac.uk/10.3390/app10176000

Chicago/Turabian Style

Contaldo, Maria, Annalisa Itro, Carlo Lajolo, Gioele Gioco, Francesco Inchingolo, and Rosario Serpico. 2020. "Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota" Applied Sciences 10, no. 17: 6000. https://0-doi-org.brum.beds.ac.uk/10.3390/app10176000

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