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Review

A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis

1
Department of Chemistry, National and Kapodistrian University of Athens, Zographou, 15784 Athens, Greece
2
Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110e Ioannina, Greece
*
Author to whom correspondence should be addressed.
Received: 13 May 2020 / Revised: 1 June 2020 / Accepted: 2 June 2020 / Published: 8 June 2020
(This article belongs to the Special Issue Advances in Multiple Sclerosis Research—Series I)
Multiple sclerosis (MS) is a serious central nervous system (CNS) disease responsible for disability problems and deterioration of the quality of life. Several approaches have been applied to medications entering the market to treat this disease. However, no effective therapy currently exists, and the available drugs simply ameliorate the destructive disability effects of the disease. In this review article, we report on the efforts that have been conducted towards establishing the conformational properties of wild-type myelin basic protein (MBP), myelin proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG) epitopes or altered peptide ligands (ALPs). These efforts have led to the aim of discovering some non-peptide mimetics possessing considerable activity against the disease. These efforts have contributed also to unveiling the molecular basis of the molecular interactions implicated in the trimolecular complex, T-cell receptor (TCR)–peptide–major histocompatibility complex (MHC) or human leucocyte antigen (HLA). View Full-Text
Keywords: conformational analysis; peptides; altered peptide ligands; multiple sclerosis; MS; NMR spectroscopy; NOE-constraints; molecular dynamic; trimolecular complex; experimental autoimmune encephalomyelitis conformational analysis; peptides; altered peptide ligands; multiple sclerosis; MS; NMR spectroscopy; NOE-constraints; molecular dynamic; trimolecular complex; experimental autoimmune encephalomyelitis
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MDPI and ACS Style

Koukoulitsa, C.; Chontzopoulou, E.; Kiriakidi, S.; Tzakos, A.G.; Mavromoustakos, T. A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis. Brain Sci. 2020, 10, 356. https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci10060356

AMA Style

Koukoulitsa C, Chontzopoulou E, Kiriakidi S, Tzakos AG, Mavromoustakos T. A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis. Brain Sciences. 2020; 10(6):356. https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci10060356

Chicago/Turabian Style

Koukoulitsa, Catherine, Eleni Chontzopoulou, Sofia Kiriakidi, Andreas G. Tzakos, and Thomas Mavromoustakos. 2020. "A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis" Brain Sciences 10, no. 6: 356. https://0-doi-org.brum.beds.ac.uk/10.3390/brainsci10060356

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