Antioxidants, Volume 10, Issue 1 (January 2021) – 138 articles
Cover Story (view full-size image): The enzyme CYP1A2 is responsible for the metabolism of caffeine into paraxanthine. Both molecules are known for their antioxidant and pro-oxidant characteristics, and the paraxanthine-to-caffeine molar ratio is a widely accepted metric for CYP1A2 phenotyping for optimizing dose–response effects in individual patients. This work presents the simultaneous quantification of caffeine and paraxanthine in spiked human saliva samples by differential pulse voltammetry using an anodically pretreated glassy carbon electrode. Potential applicability of the sensing platform was demonstrated by running a small-scale trial on five healthy volunteers. The results were validated by ultra-high-pressure liquid chromatography and shown to have a high correlation factor (r = 0.994). View this paper
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