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Review

Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer

by 1,2,†, 1,2,†, 1,2,3,†, 4,5, 1,2,6,7, 1,7,8,* and 2,5,6,9,*
1
School of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
Research Center for Emerging Viral, Infections Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan
3
Department of Medical Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan
4
Division of Gastroenterology and Hepatology, Department of Internal Medicine, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan
5
Department of Internal Medicine, Department of Medical Research, School of Medicine, China Medical University and Hospital, Taichung 40447, Taiwan
6
Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan
7
Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan
8
Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan
9
Department of Nursing, Asia University, Taichung 41354, Taiwan
*
Authors to whom correspondence should be addressed.
Equal contribution to this work.
Academic Editors: Debasis Mondal and Syed Siraj A. Quadri
Received: 20 July 2021 / Revised: 12 August 2021 / Accepted: 13 August 2021 / Published: 16 August 2021
Conventionally, statins are used to treat high cholesterol levels. They exhibit pleiotropic effects, such as the prevention of cardiovascular disease and decreased cancer mortality. Gastric cancer (GC) is one of the most common cancers, ranking as the third leading global cause of cancer-related deaths, and is mainly attributed to chronic Helicobacter pylori infection. During their co-evolution with hosts, H. pylori has developed the ability to use the cellular components of the host to evade the immune system and multiply in intracellular niches. Certain H. pylori virulence factors, including cytotoxin-associated gene A (CagA), vacuolating cytotoxin A (VacA), and cholesterol-α-glucosyltransferase (CGT), have been shown to exploit host cholesterol during pathogenesis. Therefore, using statins to antagonize cholesterol synthesis might prove to be an ideal strategy for reducing the occurrence of H. pylori-related GC. This review discusses the current understanding of the interplay of H. pylori virulence factors with cholesterol and reactive oxygen species (ROS) production, which may prove to be novel therapeutic targets for the development of effective treatment strategies against H. pylori-associated GC. We also summarize the findings of several clinical studies on the association between statin therapy and the development of GC, especially in terms of cancer risk and mortality. View Full-Text
Keywords: statin; gastric cancer; cholesterol; reactive oxygen species; Helicobacter pylori statin; gastric cancer; cholesterol; reactive oxygen species; Helicobacter pylori
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MDPI and ACS Style

Lin, T.-Y.; Lan, W.-H.; Chiu, Y.-F.; Feng, C.-L.; Chiu, C.-H.; Kuo, C.-J.; Lai, C.-H. Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer. Antioxidants 2021, 10, 1293. https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10081293

AMA Style

Lin T-Y, Lan W-H, Chiu Y-F, Feng C-L, Chiu C-H, Kuo C-J, Lai C-H. Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer. Antioxidants. 2021; 10(8):1293. https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10081293

Chicago/Turabian Style

Lin, Ting-Yu, Wen-Hsi Lan, Ya-Fang Chiu, Chun-Lung Feng, Cheng-Hsun Chiu, Chia-Jung Kuo, and Chih-Ho Lai. 2021. "Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer" Antioxidants 10, no. 8: 1293. https://0-doi-org.brum.beds.ac.uk/10.3390/antiox10081293

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