Next Article in Journal
Molecular Mechanism of Oxidation of P700 and Suppression of ROS Production in Photosystem I in Response to Electron-Sink Limitations in C3 Plants
Previous Article in Journal
The Role of Selected Bioactive Compounds in the Prevention of Alzheimer’s Disease
Review

Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage

1
MARE—Marine and Environmental Sciences Centre, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, Portugal
2
REQUIMTE/LAQV, Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
Received: 12 February 2020 / Revised: 4 March 2020 / Accepted: 8 March 2020 / Published: 11 March 2020
(This article belongs to the Section Natural and Synthetic Antioxidants)
Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety. Therefore, it has been the subject of extensive scientific research concerning the possibilities to reduce it, both in vivo and in nonliving organic matrices. It can be started by a variety of oxidants, by both ROS-dependent and -independent pathways, all of them reviewed in this document. Another feature of this reaction is the capacity of lipid peroxyl radicals to react with the non-oxidized lipids, propagating the reaction even in the absence of an external trigger. Due to these specificities of lipid peroxidation, regular antioxidant strategies—although being helpful in controlling oxidative triggers—are not tailored to tackle this challenge. Thus, more suited antioxidant compounds or technologies are required and sought after by researchers, either in the fields of medicine and physiology, or in product development and biotechnology. Despite the existence of several laboratory procedures associated with the study of lipid peroxidation, a methodology to perform bioprospecting of natural products to prevent lipid peroxidation (a Lipid Peroxidation Inhibitory Potential assay, LPIP) is not yet well established. In this review, a critical look into the possibility of testing the capacity of natural products to inhibit lipid peroxidation is presented. In vitro systems used to peroxidize a lipid sample are also reviewed on the basis of lipid substrate origin, and, for each of them, procedural insights, oxidation initiation strategies, and lipid peroxidation extent monitoring are discussed. View Full-Text
Keywords: lipid peroxidation; LPIP; natural products; bioactive compounds; in vitro lipid peroxidation; LPIP; natural products; bioactive compounds; in vitro
Show Figures

Figure 1

MDPI and ACS Style

Félix, R.; Valentão, P.; Andrade, P.B.; Félix, C.; Novais, S.C.; Lemos, M.F.L. Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage. Antioxidants 2020, 9, 231. https://0-doi-org.brum.beds.ac.uk/10.3390/antiox9030231

AMA Style

Félix R, Valentão P, Andrade PB, Félix C, Novais SC, Lemos MFL. Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage. Antioxidants. 2020; 9(3):231. https://0-doi-org.brum.beds.ac.uk/10.3390/antiox9030231

Chicago/Turabian Style

Félix, Rafael, Patrícia Valentão, Paula B. Andrade, Carina Félix, Sara C. Novais, and Marco F.L. Lemos 2020. "Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage" Antioxidants 9, no. 3: 231. https://0-doi-org.brum.beds.ac.uk/10.3390/antiox9030231

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop