Vaccines, Volume 9, Issue 1 (January 2021) – 66 articles
Cover Story (view full-size image): Influenza viruses remain a constant burden in humans, causing millions of infections and hundreds of thousands of deaths each year. Current influenza virus vaccines are often strain-specific, meaning limited cross-protection against divergent viruses, resulting in poor vaccine efficacy. Yearly influenza vaccination is an expensive and time-consuming exercise, and the constant arms race between host immunity and virus evolution presents an ongoing challenge for efficacy. Additionally, there exists the constant pandemic threat of highly pathogenic avian influenza viruses with high fatality rates (~30–50%) or the emergence of new, pathogenic reassortants, highlighting the urgent need for improved influenza virus vaccines. Here, we review the next generation of influenza virus vaccines and the steps being taken to achieve universal protection. View this paper.
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