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Article

Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm

1
Virus Disease Division, Animal and Plant Quarantine Agency, Gimchen, Gyeongbuk-do 39660, Korea
2
Korea Pork Producers Association, Seocho-gu, Seoul 06643, Korea
3
Pig Integrated Control Center (PICC), Cheonan City 31008, Korea
4
College of Veterinary Medicine, Seoul University, Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
These authors made an equal contribution.
Academic Editor: Lester J. Perez
Received: 21 March 2021 / Revised: 8 April 2021 / Accepted: 10 April 2021 / Published: 13 April 2021
Herein, we compared the productivity of pigs inoculated with one of two classical swine fever (CSF) vaccines (low virulent of Miyagi (LOM) or Flc-LOM-BErns) plus the swine erysipelothrix rhusiopathiae (SE) vaccine. The feed intake and weight increase of the pigs inoculated with Flc-LOM-BErns + SE were normal. However, the feed intake of the pigs inoculated with LOM + SE dropped sharply from four days post-vaccination (dpv). In addition, the slaughter date was an average of eight days later than that of the pigs inoculated with Flc-LOM-BErns + SE. All pigs inoculated with the Flc-LOM-BErns + SE vaccine were completely differentiated at 14 days against CSF Erns antibody and at approximately 45 days against the bovine viral diarrhea virus (BVDV) Erns antibody; the titers were maintained until slaughter. Leucopenia occurred temporarily in the LOM + SE group, but not in the Flc-LOM-BErns + SE group. Expression of tumor necrosis factor (TNF)-α and IFN-γ was significantly (p < 0.05) higher in the LOM + SE group than in the mock (no vaccine) group. When conducting the same experiment on a breeding farm, the results were similar to those of the laboratory experiments. In conclusion, the biggest advantage of replacing the CSF LOM vaccine with the Flc-LOM-BErns vaccine is improved productivity. View Full-Text
Keywords: CSFV; LOM; Flc-LOM-BErns; SE; DIVA; pig CSFV; LOM; Flc-LOM-BErns; SE; DIVA; pig
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MDPI and ACS Style

Choe, S.; Kim, K.-S.; Shin, J.; Song, S.; Park, G.-N.; Cha, R.M.; Choi, S.-H.; Jung, B.-I.; Lee, K.-W.; Hyun, B.-H.; Park, B.-K.; An, D.-J. Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm. Vaccines 2021, 9, 381. https://0-doi-org.brum.beds.ac.uk/10.3390/vaccines9040381

AMA Style

Choe S, Kim K-S, Shin J, Song S, Park G-N, Cha RM, Choi S-H, Jung B-I, Lee K-W, Hyun B-H, Park B-K, An D-J. Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm. Vaccines. 2021; 9(4):381. https://0-doi-org.brum.beds.ac.uk/10.3390/vaccines9040381

Chicago/Turabian Style

Choe, SeEun, Ki-Sun Kim, Jihye Shin, Sok Song, Gyu-Nam Park, Ra M. Cha, Sung-Hyun Choi, Byung-Il Jung, Kyung-Won Lee, Bang-Hun Hyun, Bong-Kyun Park, and Dong-Jun An. 2021. "Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns) from Laboratory to Pig Farm" Vaccines 9, no. 4: 381. https://0-doi-org.brum.beds.ac.uk/10.3390/vaccines9040381

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