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Article

The Influence of Air Pollution on the Development of Allergic Inflammation in the Airways in Krakow’s Atopic and Non-Atopic Residents

1
Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Botaniczna St. 3, 31-501 Krakow, Poland
2
Department of Biocybernetics and Biomedical Engineering, AGH University of Science and Technology, Mickiewicza Av. 30, 30-059 Krakow, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Artur Badyda, Tamara Schikowski and Andrzej Chcialowski
J. Clin. Med. 2021, 10(11), 2383; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10112383
Received: 30 March 2021 / Revised: 24 May 2021 / Accepted: 24 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue Clinical Studies on the Impact of Air Pollutants on Human Health)
Until now, the simultaneous influence of air pollution assessed by measuring the objective marker of exposition (1-hydroxypirene, 1-OHP) and atopy on the development of allergic airway diseases has not been studied. The aim of this study was to determine the pathomechanism of the allergic response to PM2.5 in atopic and non-atopic patients. We investigated the changes in peripheral blood basophil activity of patients after stimulation with the birch pollen allergen alone, the allergen combined with PM2.5 (BP), PM2.5 alone, a concentration of 1-OHP in urine, and a distance of residence from the main road in 30 persons. Activation by dust alone was positive for all concentrations in 83% of atopic and 75% of non-atopic assays. In the group of people with atopy, the simultaneous activation of BP gave a higher percentage of active basophils compared to the sum of activation with dust and birch pollen alone (B + P) for all concentrations. The difference between BP and B + P was 117.5 (p = 0.02) at a PM concentration of 100 μg. Such a relationship was not observed in the control group. The correlation coefficient between the distance of residence from major roads and urinary 1-OHP was 0.62. A Pearson correlation analysis of quantitative variables was performed, and positive correlation results were obtained in the atopy group between BP and 1-OH-P. Exposure to birch pollen and PM2.5 has a synergistic effect in sensitized individuals. The higher the exposure to pollutants, the higher the synergistic basophil response to the allergen and PM in atopic patients. View Full-Text
Keywords: air pollution; respiratory health; allergic inflammation air pollution; respiratory health; allergic inflammation
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MDPI and ACS Style

Czarnobilska, E.; Bulanda, M.; Bulanda, D.; Mazur, M. The Influence of Air Pollution on the Development of Allergic Inflammation in the Airways in Krakow’s Atopic and Non-Atopic Residents. J. Clin. Med. 2021, 10, 2383. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10112383

AMA Style

Czarnobilska E, Bulanda M, Bulanda D, Mazur M. The Influence of Air Pollution on the Development of Allergic Inflammation in the Airways in Krakow’s Atopic and Non-Atopic Residents. Journal of Clinical Medicine. 2021; 10(11):2383. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10112383

Chicago/Turabian Style

Czarnobilska, Ewa, Małgorzata Bulanda, Daniel Bulanda, and Marcel Mazur. 2021. "The Influence of Air Pollution on the Development of Allergic Inflammation in the Airways in Krakow’s Atopic and Non-Atopic Residents" Journal of Clinical Medicine 10, no. 11: 2383. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10112383

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