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Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis Patients

1
College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
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Division of Cardiology, Department of Internal Medicine, Cathay General Hospital, Taipei 106, Taiwan
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Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan
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Department of Community Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan
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Renal Care Joint Foundation, New Taipei City 220, Taiwan
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Graduate Institution of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
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Department of Civil Engineering, National Taiwan University, Taipei 106, Taiwan
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School of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan
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Department of Medical Research and Education, Cheng Hsin General Hospital, Taipei 112, Taiwan
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Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan
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Ph.D. Program in Nutrition and Food Science, College of Human Ecology, Fu Jen Catholic University, New Taipei City 242, Taiwan
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 10 September 2018 / Accepted: 21 September 2018 / Published: 24 September 2018
(This article belongs to the Section Vascular Medicine)
Background: Interactions and joint effects of galectin-3 and vascular cell adhesion molecule 1 (VCAM-1) on risks of all-cause and cardiovascular (CV) mortality remain unclear in patients with maintenance hemodialysis (MHD). Methods: Unadjusted and adjusted hazard ratios (aHRs) of mortality risks were analyzed between higher and lower concentration groups of serum galectin-3 and VCAM-1. The modification effect between serum galectin-3 and VCAM-1 on mortality risk was investigated using an interaction product term. Results: During follow-up, galectin-3 and VCAM-1 were associated with incremental risks of all-cause mortality (aHR: 1.038 (95% confidence interval (CI): 1.001–1.077) and 1.002 (95% CI: 1.001–1.003), respectively). Nonetheless, VCAM-1 but not galectin-3 predicted CV mortality (aHR: 1.043 (95% CI: 0.993–1.096) and 1.002 (95% CI: 1.001–1.003), respectively). In the interaction analysis, patients with combined higher galectin-3 (>29.5 ng/mL) and VCAM-1 (>1546.9 ng/mL) were at the greatest risk of all-cause and CV mortality (aHR: 4.6 (95% CI: 1.6–13.4), and 4.2 (95% CI: 1.3–14.4), respectively). The interactions between galectin-3 and VCAM-1 with respect to all-cause and CV mortality were statistically significant (p < 0.01 and < 0.05, respectively). Conclusion: Galectin-3 and VCAM-1 could serve as a promising dual biomarker for prognostic assessment, considering their joint effects on pathogenesis of leukocyte trafficking and atherothrombosis. View Full-Text
Keywords: galectin; cell adhesion molecules; mortality; hemodialysis galectin; cell adhesion molecules; mortality; hemodialysis
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MDPI and ACS Style

Ko, W.-C.; Choy, C.-S.; Lin, W.-N.; Chang, S.-W.; Liou, J.-C.; Tung, T.-H.; Hsieh, C.-Y.; Chang, J.-F. Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis Patients. J. Clin. Med. 2018, 7, 300. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm7100300

AMA Style

Ko W-C, Choy C-S, Lin W-N, Chang S-W, Liou J-C, Tung T-H, Hsieh C-Y, Chang J-F. Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis Patients. Journal of Clinical Medicine. 2018; 7(10):300. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm7100300

Chicago/Turabian Style

Ko, Wen-Chin, Cheuk-Sing Choy, Wei-Ning Lin, Shu-Wei Chang, Jian-Chiun Liou, Tao-Hsin Tung, Chih-Yu Hsieh, and Jia-Feng Chang. 2018. "Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis Patients" Journal of Clinical Medicine 7, no. 10: 300. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm7100300

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