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Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis

1
School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada
2
Community Health and Epidemiology, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada
*
Author to whom correspondence should be addressed.
Received: 22 October 2018 / Revised: 14 November 2018 / Accepted: 14 November 2018 / Published: 16 November 2018
(This article belongs to the Special Issue Treatment of Bipolar Depression)
The purpose of this study is to conduct a systematic review and meta-analysis to evaluate the risk of depression and suicidality among diabetic patients. Methods: Medline, PubMed, EMBASE, Cochrane library, and Psych INFO were searched for studies published from 2008 onwards. Meta-analysis was conducted to estimate the pooled effect size. Sources of heterogeneity were investigated by subgroup analysis and meta-regression. Results: In total, 5750 articles were identified and of those, 17 studies on suicidality and 36 on depression were included in this study. Our analysis suggests a positive relationship between diabetes and depression (cohort studies odds ratio (OR) 1.49, 95% confidence interval (CI): 1.36–1.64 and cross-sectional studies OR 2.04, 95% CI, 1.73–2.42). Pooled OR values for suicidal ideation, attempted suicide, and completed suicide were 1.89 (95% CI: 1.36–2.63), 1.45 (95% CI: 1.07–1.96), and 1.85 (95% CI: 0.97–3.52), respectively. All findings were statistically significant except for completed suicide. Conclusions: The increased risk of depression and suicidality in diabetic patients highlights the importance of integrating the evaluation and treatment of depression with diabetes management in primary healthcare settings. Further research in this area is needed. View Full-Text
Keywords: diabetes; depression; suicide; suicidal ideation; suicidal attempts; suicidal death diabetes; depression; suicide; suicidal ideation; suicidal attempts; suicidal death
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MDPI and ACS Style

Elamoshy, R.; Bird, Y.; Thorpe, L.; Moraros, J. Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis. J. Clin. Med. 2018, 7, 445. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm7110445

AMA Style

Elamoshy R, Bird Y, Thorpe L, Moraros J. Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2018; 7(11):445. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm7110445

Chicago/Turabian Style

Elamoshy, Rasha, Yelena Bird, Lilian Thorpe, and John Moraros. 2018. "Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 7, no. 11: 445. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm7110445

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