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Article

Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS)

1
Toyama Regional Center for Japan Environment and Children’s Study, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan
2
Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan
3
JECS Programme Office, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan
*
Author to whom correspondence should be addressed.
Membership of JECS Group is provided in the Acknowledgments.
Received: 27 April 2020 / Revised: 30 May 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Clinical Studies on the Impact of Air Pollutants on Human Health)
Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective relationship between air-purifier usage during pregnancy and infant developmental delay by analyzing 82,441 mother–infant pairs using a simple yes/no questionnaire. Developmental delays at 6 and 12 months were assessed in five areas using the Ages and Stages Questionnaire, Third Edition. A generalized linear mixed model analysis was used to derive adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) while controlling for 20 covariates. The analysis revealed that air-purifier usage was associated with developmental delays in fine motor (AOR: 0.91, 95% CI: 0.83–0.99) and problem solving (AOR: 0.83, 95% CI: 0.77–0.90) at 6 months and in communication (AOR: 0.86, 95% CI: 0.79–0.93), fine motor (AOR: 0.87, 95% CI: 0.82–0.92), problem solving (AOR: 0.83, 95% CI: 0.77–0.88), and personal–social (AOR: 0.79, 95% CI: 0.72–0.86) at 12 months. In conclusion, a negative association exists between air-purifier usage during pregnancy and infant neurodevelopmental delay that strengthens with time. Our results outline the potential role of air purifiers in inhibiting infant neurodevelopmental delay. View Full-Text
Keywords: air purifier; air cleaner; developmental delay; dwelling environment; indoor environment; birth cohort air purifier; air cleaner; developmental delay; dwelling environment; indoor environment; birth cohort
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MDPI and ACS Style

Matsumura, K.; Hamazaki, K.; Tsuchida, A.; Inadera, H.; The Japan Environment and Children’s Study Group. Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS). J. Clin. Med. 2020, 9, 1924. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm9061924

AMA Style

Matsumura K, Hamazaki K, Tsuchida A, Inadera H, The Japan Environment and Children’s Study Group. Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS). Journal of Clinical Medicine. 2020; 9(6):1924. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm9061924

Chicago/Turabian Style

Matsumura, Kenta, Kei Hamazaki, Akiko Tsuchida, Hidekuni Inadera, and The Japan Environment and Children’s Study Group. 2020. "Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS)" Journal of Clinical Medicine 9, no. 6: 1924. https://0-doi-org.brum.beds.ac.uk/10.3390/jcm9061924

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