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Article

Electrospun Poly(butylene-adipate-co-terephthalate)/Nano-hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone

1
Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Sao Paulo State University, Sao Paulo 12450-000, Brazil
2
Air Force Academy, Brazilian Air Force, Pirassununga 13630-000, Brazil
3
LIMAV—Interdisciplinary Laboratory for Advanced Materials, UFPI-Federal University of Piaui, Teresina 64049-550, Brazil
4
Instituto Científico e Tecnológico, Universidade Brasil, Sao Paulo 12450-000, Brazil
5
Department of Physics, Federal University of Piaui, Teresina 64049-550, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editor: Giuseppe Perale
J. Funct. Biomater. 2021, 12(1), 11; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010011
Received: 5 January 2021 / Revised: 25 January 2021 / Accepted: 27 January 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Fibrous Scaffolds for Tissue Engineering Application)
Electrospun ultrathin fibrous scaffold filed with synthetic nanohydroxyapatite (nHAp) and graphene nanoribbons (GNR) has bioactive and osteoconductive properties and is a plausible strategy to improve bone regeneration. Poly(butylene-adipate-co-terephthalate) (PBAT) has been studied as fibrous scaffolds due to its low crystallinity, faster biodegradability, and good mechanical properties; however, its potential for in vivo applications remains underexplored. We proposed the application of electrospun PBAT with high contents of incorporated nHAp and nHAp/GNR nanoparticles as bone grafts. Ultrathin PBAT, PBAT/nHAp, and PBAT/nHAp/GNR fibers were produced using an electrospinning apparatus. The produced fibers were characterized morphologically and structurally using scanning electron (SEM) and high-resolution transmission electron (TEM) microscopies, respectively. Mechanical properties were analyzed using a texturometer. All scaffolds were implanted into critical tibia defects in rats and analyzed after two weeks using radiography, microcomputed tomography, histological, histomorphometric, and biomechanical analyses. The results showed through SEM and high-resolution TEM characterized the average diameters of the fibers (ranged from 0.208 µm ± 0.035 to 0.388 µm ± 0.087) and nHAp (crystallite around 0.28, 0.34, and 0.69 nm) and nHAp/GNR (200–300 nm) nanoparticles distribution into PBAT matrices. Ultrathin fibers were obtained, and the incorporated nHAp and nHAp/GNR nanoparticles were well distributed into PBAT matrices. The addition of nHAp and nHAp/GNR nanoparticles improved the elastic modulus of the ultrathin fibers compared to neat PBAT. High loads of nHAp/GNR (PBATnH5G group) improved the in vivo lamellar bone formation promoting greater radiographic density, trabecular number and stiffness in the defect area 2 weeks after implantation than control and PBAT groups. View Full-Text
Keywords: electrospinning; nano-hydroxyapatite; graphene nanoribbons; PBAT; bone regeneration electrospinning; nano-hydroxyapatite; graphene nanoribbons; PBAT; bone regeneration
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MDPI and ACS Style

Vasconcellos, L.M.R.; Santana-Melo, G.F.; Silva, E.; Pereira, V.F.; Araújo, J.C.R.; Silva, A.D.R.; Furtado, A.S.A.; Elias, C.d.M.V.; Viana, B.C.; Marciano, F.R.; Lobo, A.O. Electrospun Poly(butylene-adipate-co-terephthalate)/Nano-hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone. J. Funct. Biomater. 2021, 12, 11. https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010011

AMA Style

Vasconcellos LMR, Santana-Melo GF, Silva E, Pereira VF, Araújo JCR, Silva ADR, Furtado ASA, Elias CdMV, Viana BC, Marciano FR, Lobo AO. Electrospun Poly(butylene-adipate-co-terephthalate)/Nano-hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone. Journal of Functional Biomaterials. 2021; 12(1):11. https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010011

Chicago/Turabian Style

Vasconcellos, Luana M.R., Gabriela F. Santana-Melo, Edmundo Silva, Vanessa F. Pereira, Juliani C.R. Araújo, André D.R. Silva, André S.A. Furtado, Conceição d.M.V. Elias, Bartolomeu C. Viana, Fernanda R. Marciano, and Anderson O. Lobo 2021. "Electrospun Poly(butylene-adipate-co-terephthalate)/Nano-hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone" Journal of Functional Biomaterials 12, no. 1: 11. https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010011

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