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Article

Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue

Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
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J. Funct. Biomater. 2021, 12(1), 8; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010008
Received: 17 December 2020 / Revised: 20 January 2021 / Accepted: 22 January 2021 / Published: 26 January 2021
While periprosthetic joint infections (PJIs) result in a small percentage of patients following arthroplasties, they are challenging to treat if they spread into bone and soft tissue. Treatment involves delivering antibiotics using poly(methyl methacrylate) (PMMA) bone cement. However, antibiotic release is insufficient for prolonged infections. Previous work demonstrated efficacy of incorporating insoluble cyclodextrin (CD) microparticles into PMMA to improve antibiotic release and allow for post-implantation drug refilling to occur in a tissue-mimicking model. To simulate how antibiotic refilling may be possible in more physiologically relevant models, this work investigated development of bone and muscle refilling models. The bone refilling model involved embedding PMMA-CD into rabbit femur and administering antibiotic via intraosseous infusion. Muscle tissue refilling model involved implanting PMMA-CD beads in bovine muscle tissue and administering antibiotic via tissue injection. Duration of antimicrobial activity of refilled PMMA-CD was evaluated. PMMA-CD composite in bone and muscle tissue models was capable of being refilled with antibiotics and resulted in prolonged antimicrobial activity. PMMA-CD provided sustained and on-demand antimicrobial activity without removal of implant if infection develops. Intraosseous infusion appeared to be a viable technique to enable refilling of PMMA-CD after implantation in bone, reporting for the first time the ability to refill PMMA in bone. View Full-Text
Keywords: PMMA; antibiotic; bone cement; refill; femur PMMA; antibiotic; bone cement; refill; femur
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MDPI and ACS Style

Cyphert, E.L.; Zhang, N.; Marques, D.W.; Learn, G.D.; Zhang, F.; von Recum, H.A. Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue. J. Funct. Biomater. 2021, 12, 8. https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010008

AMA Style

Cyphert EL, Zhang N, Marques DW, Learn GD, Zhang F, von Recum HA. Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue. Journal of Functional Biomaterials. 2021; 12(1):8. https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010008

Chicago/Turabian Style

Cyphert, Erika L., Ningjing Zhang, Dylan W. Marques, Greg D. Learn, Fang Zhang, and Horst A. von Recum 2021. "Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue" Journal of Functional Biomaterials 12, no. 1: 8. https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12010008

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