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Review

Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H2O2

1
Department of Environment Science and Engineering, Kyung Hee University, Yongin 446-701, Korea
2
Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha, Qatar
3
Department of Mechanical and Industrial Engineering, Qatar University, P.O. Box 2713, Doha, Qatar
4
Department of Computer Engineering, Qatar University, P.O. Box 2713, Doha, Qatar
5
Weill Cornell Medicine-Qatar, Qatar Foundation-Education City, P.O. Box 24144, Doha, Qatar
*
Authors to whom correspondence should be addressed.
Received: 12 September 2020 / Revised: 5 October 2020 / Accepted: 12 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue Advance Nanomaterials for Biosensors)
Non-enzymatic sensing has been in the research limelight, and most sensors based on nanomaterials are designed to detect single analytes. The simultaneous detection of analytes that together exist in biological organisms necessitates the development of effective and efficient non-enzymatic electrodes in sensing. In this regard, the development of sensing elements for detecting glucose and hydrogen peroxide (H2O2) is significant. Non-enzymatic sensing is more economical and has a longer lifetime than enzymatic electrochemical sensing, but it has several drawbacks, such as high working potential, slow electrode kinetics, poisoning from intermediate species and weak sensing parameters. We comprehensively review the recent developments in non-enzymatic glucose and H2O2 (NEGH) sensing by focusing mainly on the sensing performance, electro catalytic mechanism, morphology and design of electrode materials. Various types of nanomaterials with metal/metal oxides and hybrid metallic nanocomposites are discussed. A comparison of glucose and H2O2 sensing parameters using the same electrode materials is outlined to predict the efficient sensing performance of advanced nanomaterials. Recent innovative approaches to improve the NEGH sensitivity, selectivity and stability in real-time applications are critically discussed, which have not been sufficiently addressed in the previous reviews. Finally, the challenges, future trends, and prospects associated with advanced nanomaterials for NEGH sensing are considered. We believe this article will help to understand the selection of advanced materials for dual/multi non-enzymatic sensing issues and will also be beneficial for researchers to make breakthrough progress in the area of non-enzymatic sensing of dual/multi biomolecules. View Full-Text
Keywords: advanced nanomaterials; dual in-line sensing; bi-functional properties; non-enzymatic; electrochemical sensing; glucose and H2O2 advanced nanomaterials; dual in-line sensing; bi-functional properties; non-enzymatic; electrochemical sensing; glucose and H2O2
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MDPI and ACS Style

Thatikayala, D.; Ponnamma, D.; Sadasivuni, K.K.; Cabibihan, J.-J.; Al-Ali, A.K.; Malik, R.A.; Min, B. Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H2O2. Biosensors 2020, 10, 151. https://0-doi-org.brum.beds.ac.uk/10.3390/bios10110151

AMA Style

Thatikayala D, Ponnamma D, Sadasivuni KK, Cabibihan J-J, Al-Ali AK, Malik RA, Min B. Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H2O2. Biosensors. 2020; 10(11):151. https://0-doi-org.brum.beds.ac.uk/10.3390/bios10110151

Chicago/Turabian Style

Thatikayala, Dayakar, Deepalekshmi Ponnamma, Kishor K. Sadasivuni, John-John Cabibihan, Abdulaziz K. Al-Ali, Rayaz A. Malik, and Booki Min. 2020. "Progress of Advanced Nanomaterials in the Non-Enzymatic Electrochemical Sensing of Glucose and H2O2" Biosensors 10, no. 11: 151. https://0-doi-org.brum.beds.ac.uk/10.3390/bios10110151

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