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Review

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma

1
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman 76169-14111, Iran
2
Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, 6720 Szeged, Hungary
3
Department of Physics, Faculty of Science, University of Zabol, Zabol 538-98615, Iran
4
Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan 98167-43463, Iran
5
Particulate Matter Research Center, Research Institute of Industrial Science & Technology (RIST), 187-12, Geumho-ro, Gwangyang-si 57801, Korea
6
Department of Chemistry, College of Natural Science, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Korea
*
Authors to whom correspondence should be addressed.
Received: 22 January 2021 / Revised: 13 February 2021 / Accepted: 15 February 2021 / Published: 20 February 2021
(This article belongs to the Special Issue Advance Nanomaterials for Biosensors)
Osteosarcoma (OSA) is a type of bone cancer that begins in the cells that form bones. OSA is a rare mesenchymal bone neoplasm derived from mesenchymal stem cells. Genome disorganization, chromosomal modifications, deregulation of tumor suppressor genes, and DNA repair defects are the factors most responsible for OSA development. Despite significant advances in the diagnosing and treatment of OSA, patients’ overall survival has not improved within the last twenty years. Lately, advances in modern nanotechnology have spurred development in OSA management and offered several advantages to overcome the drawbacks of conventional therapies. This technology has allowed the practical design of nanoscale devices combined with numerous functional molecules, including tumor-specific ligands, antibodies, anti-cancer drugs, and imaging probes. Thanks to their small sizes, desirable drug encapsulation efficiency, and good bioavailability, functionalized nanomaterials have found wide-spread applications for combating OSA progression. This review invokes the possible utility of engineered nanomaterials in OSA diagnosis and treatment, motivating the researchers to seek new strategies for tackling the challenges associated with it. View Full-Text
Keywords: nanotechnology; bone diseases; drug delivery; nanocarriers; osteosarcoma; tumor-targeted nanotechnology; bone diseases; drug delivery; nanocarriers; osteosarcoma; tumor-targeted
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MDPI and ACS Style

Barani, M.; Mukhtar, M.; Rahdar, A.; Sargazi, S.; Pandey, S.; Kang, M. Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma. Biosensors 2021, 11, 55. https://0-doi-org.brum.beds.ac.uk/10.3390/bios11020055

AMA Style

Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M. Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma. Biosensors. 2021; 11(2):55. https://0-doi-org.brum.beds.ac.uk/10.3390/bios11020055

Chicago/Turabian Style

Barani, Mahmood, Mahwash Mukhtar, Abbas Rahdar, Saman Sargazi, Sadanand Pandey, and Misook Kang. 2021. "Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma" Biosensors 11, no. 2: 55. https://0-doi-org.brum.beds.ac.uk/10.3390/bios11020055

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