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Review

Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

1
Institute of Applied Sciences and Intelligent Systems, Unit of Naples, National Research Council, Via P. Castellino 111, 80131 Napoli, Italy
2
Department of Electrical Engineering and Information Technology, University of Naples Federico II, Via Claudio 21, 80125 Napoli, Italy
*
Author to whom correspondence should be addressed.
Received: 23 February 2021 / Revised: 20 March 2021 / Accepted: 31 March 2021 / Published: 4 April 2021
(This article belongs to the Special Issue Feature Issue of Biosensors and Bioelectronic Devices Section)
Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advantage of adapting to non-planar surfaces, suitable for in vivo and real-time monitoring of diseases and assessment of food safety. In this review, we summarize the newest and most advanced platforms coupling optically active materials (noble metal nanoparticles) and flexible substrates giving rise to hybrid nanomaterials and/or nanocomposites, whose performances are comparable to the ones obtained with hard substrates (e.g., glass and semiconductors). We focus on localized surface plasmon resonance (LSPR)-based and surface-enhanced Raman spectroscopy (SERS)-based biosensors. We show that large-scale, cost-effective plasmonic platforms can be realized with the currently available techniques and we emphasize the open issues associated with this topic. View Full-Text
Keywords: optical biosensors; flexible hybrid materials; disease early-diagnosis; nanofabrication techniques; nanocomposite materials; LSPR-based biosensors; SERS-based biosensors optical biosensors; flexible hybrid materials; disease early-diagnosis; nanofabrication techniques; nanocomposite materials; LSPR-based biosensors; SERS-based biosensors
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MDPI and ACS Style

Miranda, B.; Rea, I.; Dardano, P.; De Stefano, L.; Forestiere, C. Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications. Biosensors 2021, 11, 107. https://0-doi-org.brum.beds.ac.uk/10.3390/bios11040107

AMA Style

Miranda B, Rea I, Dardano P, De Stefano L, Forestiere C. Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications. Biosensors. 2021; 11(4):107. https://0-doi-org.brum.beds.ac.uk/10.3390/bios11040107

Chicago/Turabian Style

Miranda, Bruno, Ilaria Rea, Principia Dardano, Luca De Stefano, and Carlo Forestiere. 2021. "Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications" Biosensors 11, no. 4: 107. https://0-doi-org.brum.beds.ac.uk/10.3390/bios11040107

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