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Communication

An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)

1
Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92831, USA
2
Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, MVD, Montevideo 11800, Uruguay
3
Laboratorio de Bacteriología Clínica, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martín, Facultad de Farmacia y Bioquímica, Buenos Aires 1120, Argentina
*
Author to whom correspondence should be addressed.
Received: 25 November 2020 / Revised: 21 December 2020 / Accepted: 23 December 2020 / Published: 26 December 2020
Acinetobacter non-baumannii species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different A. non-baumannii species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of A. non-baumannii pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of A. calcoaceticus, A. lwoffii, A. junii, A. soli, A. ursingii, A. bereziniae, A. nosocomialis, A. portensis, A. guerrae, A. baylyi, A. calcoaceticus, A. disperses, A. johnsonii, A. junii, A. lwoffii, A. nosocomialis, A. oleivorans, A. oryzae, A. pittii, A. radioresistens, and A. venetianus. The most common genes were those coding for different β-lactamases, including the carbapenemase genes blaNDM-1 and blaOXA-58. A. pittii was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being aph(6)-Id, ant(3″)-IIa, and aph(3″)-Ib, and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about A. non-baumannii resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about A. non-baumannii resistomes. View Full-Text
Keywords: Acinetobacter non-baumannii; antimicrobial resistance; resistome Acinetobacter non-baumannii; antimicrobial resistance; resistome
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MDPI and ACS Style

Baraka, A.; Traglia, G.M.; Montaña, S.; Tolmasky, M.E.; Ramirez, M.S. An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs). Antibiotics 2021, 10, 16. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010016

AMA Style

Baraka A, Traglia GM, Montaña S, Tolmasky ME, Ramirez MS. An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs). Antibiotics. 2021; 10(1):16. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010016

Chicago/Turabian Style

Baraka, Adam, German M. Traglia, Sabrina Montaña, Marcelo E. Tolmasky, and Maria S. Ramirez. 2021. "An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)" Antibiotics 10, no. 1: 16. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010016

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