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Review

Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing

1
Escuela de Ingeniería Química, Universidad del Valle, A.A., Cali 25360, Colombia
2
Grupo de Investigación en Simulación, Diseño, Control y Optimización de Procesos (SIDCOP), Departamento de Ingeniería Química, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia
*
Author to whom correspondence should be addressed.
Received: 23 December 2020 / Revised: 11 January 2021 / Accepted: 12 January 2021 / Published: 18 January 2021
Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically co-formulated with broad-spectrum β‑lactam antibiotics such as amoxicillin, conferring them high potential to treat diseases caused by bacteria that possess β‑lactam resistance. The clinical importance of CA and the complexity of the production process motivate improvements from an interdisciplinary standpoint by integrating metabolic engineering strategies and knowledge on metabolic and regulatory events through systems biology and multi-omics approaches. In the large-scale bioprocessing, optimization of culture conditions, bioreactor design, agitation regime, as well as advances in CA separation and purification are required to improve the cost structure associated to CA production. This review presents the recent insights in CA production by S. clavuligerus, emphasizing on systems biology approaches, strain engineering, and downstream processing. View Full-Text
Keywords: clavulanic acid; Streptomyces clavuligerus; systems biology; strain engineering; downstream processing clavulanic acid; Streptomyces clavuligerus; systems biology; strain engineering; downstream processing
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MDPI and ACS Style

López-Agudelo, V.A.; Gómez-Ríos, D.; Ramirez-Malule, H. Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing. Antibiotics 2021, 10, 84. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010084

AMA Style

López-Agudelo VA, Gómez-Ríos D, Ramirez-Malule H. Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing. Antibiotics. 2021; 10(1):84. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010084

Chicago/Turabian Style

López-Agudelo, Víctor A., David Gómez-Ríos, and Howard Ramirez-Malule. 2021. "Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing" Antibiotics 10, no. 1: 84. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010084

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