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Open AccessArticle

Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris

1
Division of Biological Science, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
2
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
3
Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Constantinos Athanassopoulos
Received: 29 December 2020 / Revised: 18 January 2021 / Accepted: 19 January 2021 / Published: 22 January 2021
Rhodomyrtone, a plant-derived principal compound isolated from Rhodomyrtus tomentosa (Myrtaceae) leaf extract, was assessed as a potential natural alternative for the treatment of acne vulgaris. The clinical efficacy of a 1% liposomal encapsulated rhodomyrtone serum was compared with a marketed 1% clindamycin gel. In a randomized and double-blind controlled clinical trial, 60 volunteers with mild to moderate acne severity were assigned to two groups: rhodomyrtone serum and clindamycin gel. The volunteers were instructed to apply the samples to acne lesions on their faces twice daily. A significant reduction in the total numbers of acne lesions was demonstrated in both treatment groups between week 2 and 8 (p < 0.05). Significant differences in acne numbers compared with the baseline were evidenced at week 2 onwards (p < 0.05). At the end of the clinical trial, the total inflamed acne counts in the 1% rhodomyrtone serum group were significantly reduced by 36.36%, comparable to 34.70% in the clindamycin-treated group (p < 0.05). Furthermore, a commercial prototype was developed, and a clinical assessment of 45 volunteers was performed. After application of the commercial prototype for 1 week, 68.89% and 28.89% of volunteers demonstrated complete and improved inflammatory acne, respectively. All of the subjects presented no signs of irritation or side effects during the treatment. Most of the volunteers (71.11%) indicated that they were very satisfied. Rhodomyrtone serum was demonstrated to be effective and safe for the treatment of inflammatory acne lesions. View Full-Text
Keywords: antibiotic; antimicrobial; rhodomyrtone; liposome; natural products; clinical trial antibiotic; antimicrobial; rhodomyrtone; liposome; natural products; clinical trial
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MDPI and ACS Style

Wunnoo, S.; Bilhman, S.; Amnuaikit, T.; Ontong, J.C.; Singh, S.; Auepemkiate, S.; Voravuthikunchai, S.P. Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris. Antibiotics 2021, 10, 108. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020108

AMA Style

Wunnoo S, Bilhman S, Amnuaikit T, Ontong JC, Singh S, Auepemkiate S, Voravuthikunchai SP. Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris. Antibiotics. 2021; 10(2):108. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020108

Chicago/Turabian Style

Wunnoo, Suttiwan; Bilhman, Siwaporn; Amnuaikit, Thanaporn; Ontong, Julalak C.; Singh, Sudarshan; Auepemkiate, Sauvarat; Voravuthikunchai, Supayang P. 2021. "Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris" Antibiotics 10, no. 2: 108. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020108

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