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Article

Higher Prevalence of Extended-Spectrum Cephalosporin-Resistant Enterobacterales in Dogs Attended for Enteric Viruses in Brazil Before and After Treatment with Cephalosporins

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Department of Animal Production and Preventive Veterinary Medicine, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu 18618000, Brazil
2
Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago 7550000, Chile
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Escuela de Medicina Veterinaria, Pontificia Universidad Católica de Chile, Santiago 8940000, Chile
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Faculty of Veterinary Medicine and Zootechnics, Universidad Cayetano Heredia of Peru, Lima 15102, Peru
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Genomics and Resistant Microbes Group, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago 7550000, Chile
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Departamento de Ecología y Biodiversidad, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8320000, Chile
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Centro de Investigación para la Sustentabilidad, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8320000, Chile
*
Authors to whom correspondence should be addressed.
Academic Editors: Nikola Puvača, Chantal Britt and Jonathan Gómez-Raja
Received: 1 January 2021 / Revised: 22 January 2021 / Accepted: 22 January 2021 / Published: 28 January 2021
The extensive use of antibiotics is a leading cause for the emergence and spread of antimicrobial resistance (AMR) among dogs. However, the impact of using antibiotics to treat viral infections on AMR remains unknown. In this study, we compared the prevalence of extended-spectrum cephalosporin-resistant Enterobacterales (ESCR-E) between dogs with a suspected infection of canine parvovirus (CPV) and canine distemper (CDV) before and after treatment with third-generation cephalosporins. We found a higher prevalence of ESCR-E faecal carriage in dogs suspected of CPV (37%) and CDV (15%) compared to dogs with noninfectious pathologies (9%) even prior to the start of their treatment. A 7-day course of ceftriaxone or ceftiofur administrated to CPV and CDV-suspected dogs substantially increased their ESCR-E faecal carriage during treatment (85% for CPV and 57% for CDV), and 4 weeks after the treatment ended (89% for CPV and 60% for CDV) when dogs were back in their households. Most of the observed resistance was carried by ESCR-E. coli carrying blaCTX-M genes. Our results suggest the need to optimize prophylactic antibiotic therapy in dogs treated for a suspected viral infection to prevent ESCR-E emergence and spread in the community. View Full-Text
Keywords: antimicrobial resistance; antimicrobial prophylaxis; canine distemper; canine parvovirus; companion animals antimicrobial resistance; antimicrobial prophylaxis; canine distemper; canine parvovirus; companion animals
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MDPI and ACS Style

Salgado-Caxito, M.; Moreno-Switt, A.I.; Paes, A.C.; Shiva, C.; Munita, J.M.; Rivas, L.; Benavides, J.A. Higher Prevalence of Extended-Spectrum Cephalosporin-Resistant Enterobacterales in Dogs Attended for Enteric Viruses in Brazil Before and After Treatment with Cephalosporins. Antibiotics 2021, 10, 122. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020122

AMA Style

Salgado-Caxito M, Moreno-Switt AI, Paes AC, Shiva C, Munita JM, Rivas L, Benavides JA. Higher Prevalence of Extended-Spectrum Cephalosporin-Resistant Enterobacterales in Dogs Attended for Enteric Viruses in Brazil Before and After Treatment with Cephalosporins. Antibiotics. 2021; 10(2):122. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020122

Chicago/Turabian Style

Salgado-Caxito, Marília, Andrea I. Moreno-Switt, Antonio C. Paes, Carlos Shiva, Jose M. Munita, Lina Rivas, and Julio A. Benavides 2021. "Higher Prevalence of Extended-Spectrum Cephalosporin-Resistant Enterobacterales in Dogs Attended for Enteric Viruses in Brazil Before and After Treatment with Cephalosporins" Antibiotics 10, no. 2: 122. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10020122

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