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Article

Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea

1
Department of Pathobiology and Preventive Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea
2
BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul 08826, Korea
3
Bacterial Disease Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea
4
Department of Biotechnology, Inje University, Gimhae 50834, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Krisztina M. Papp-Wallace
Received: 5 January 2021 / Revised: 25 February 2021 / Accepted: 25 February 2021 / Published: 3 March 2021
(This article belongs to the Section Antibiotics Use and Antimicrobial Stewardship)
The emergence of extended-spectrum cephalosporin (ESC)-resistant Gram-negative bacteria is of great concern in both human and veterinary medicine. The aim of this study was to investigate ESC-resistant bacterial isolates from companion animals in South Korea between 2017 and 2019. Isolates with ESC resistance genes, which were identified by PCR, were assessed for genetic relatedness by multi-locus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). In total, 91 ESC-resistant Escherichia coli, Klebsiella spp., Serratia spp., and Enterobacter cloacae isolates harbored the blaTEM gene. Among other ESC resistance genes, blaCTX-M-15, blaCIT, and blaCTX-M-55 were predominantly detected in E. coli isolates, whereas blaSHV and blaDHA were more frequently detected in Klebsiella pneumoniae isolates. In addition, all blaEBC-positive isolates were classified as E. cloacae. From the MLST results, blaCTX-M-9-carrying ST131, blaCIT-carrying ST405, and blaCTX-M-1-carrying ST3285 strains were dominant among E. coli isolates. ST273 and ST275 strains harboring blaSHV were frequently detected in K. pneumoniae isolates. Various sequence types were obtained in E. cloacae and Klebsiella oxytoca isolates. All isolates demonstrated unique PFGE profiles (<57–98% similarity) and were unlikely to be derived from a single clone. The present study reveals the presence and wide genetic distribution of ESC-resistant bacterial species in South Korean companion animals. View Full-Text
Keywords: extended-spectrum cephalosporins; extended-spectrum β-lactamases; AmpC β-lactamases; antimicrobial resistance; Gram-negative bacteria; companion animal extended-spectrum cephalosporins; extended-spectrum β-lactamases; AmpC β-lactamases; antimicrobial resistance; Gram-negative bacteria; companion animal
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MDPI and ACS Style

Shin, S.R.; Noh, S.M.; Jung, W.K.; Shin, S.; Park, Y.K.; Moon, D.C.; Lim, S.-K.; Park, Y.H.; Park, K.T. Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea. Antibiotics 2021, 10, 249. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10030249

AMA Style

Shin SR, Noh SM, Jung WK, Shin S, Park YK, Moon DC, Lim S-K, Park YH, Park KT. Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea. Antibiotics. 2021; 10(3):249. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10030249

Chicago/Turabian Style

Shin, Se R., Seong M. Noh, Woo K. Jung, Sook Shin, Young K. Park, Dong C. Moon, Suk-Kyung Lim, Yong H. Park, and Kun T. Park 2021. "Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea" Antibiotics 10, no. 3: 249. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10030249

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