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Review

Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing

1
Laboratory of Biological Electron Microscopy, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
2
Unité Facultaire d’Anatomie et de Morphologie (UFAM), CUMRL, University of Lausanne, 1005 Lausanne, Switzerland
3
International Joint Research Group VUB-EPFL NanoBiotechnology and NanoMedicine (NANO), Vrije Universiteit Brussel, 1050 Brussels, Belgium
4
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, and CONICET, Diagonal 113 y 64, 1900 La Plata, Argentina
5
Centro de Investigación y Desarrollo en Fermentaciones Industriales (CINDEFI-CONICET-CCT La Plata), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
6
Research Group Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Enzo Palombo
Received: 16 February 2021 / Revised: 26 February 2021 / Accepted: 7 March 2021 / Published: 10 March 2021
(This article belongs to the Special Issue Metabolic Profiling for Microbial Resistance)
Rapid antibiotic susceptibility testing (AST) could play a major role in fighting multidrug-resistant bacteria. Recently, it was discovered that all living organisms oscillate in the range of nanometers and that these oscillations, referred to as nanomotion, stop as soon the organism dies. This finding led to the development of rapid AST techniques based on the monitoring of these oscillations upon exposure to antibiotics. In this review, we explain the working principle of this novel technique, compare the method with current ASTs, explore its application and give some advice about its implementation. As an illustrative example, we present the application of the technique to the slowly growing and pathogenic Bordetella pertussis bacteria. View Full-Text
Keywords: rapid antibiotic susceptibility testing (AST); nanomotion; atomic force microscopy (AFM); B. pertussis rapid antibiotic susceptibility testing (AST); nanomotion; atomic force microscopy (AFM); B. pertussis
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MDPI and ACS Style

Kasas, S.; Malovichko, A.; Villalba, M.I.; Vela, M.E.; Yantorno, O.; Willaert, R.G. Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing. Antibiotics 2021, 10, 287. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10030287

AMA Style

Kasas S, Malovichko A, Villalba MI, Vela ME, Yantorno O, Willaert RG. Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing. Antibiotics. 2021; 10(3):287. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10030287

Chicago/Turabian Style

Kasas, Sandor, Anton Malovichko, Maria I. Villalba, María E. Vela, Osvaldo Yantorno, and Ronnie G. Willaert 2021. "Nanomotion Detection-Based Rapid Antibiotic Susceptibility Testing" Antibiotics 10, no. 3: 287. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10030287

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