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Article

Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035

1
School of Light Industry, Beijing Technology and Business University, Beijing 100048, China
2
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
3
CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
4
Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
5
Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 211166, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Gary A. Strobel
Received: 28 February 2021 / Revised: 31 March 2021 / Accepted: 1 April 2021 / Published: 3 April 2021
(This article belongs to the Special Issue Novel Fungal Metabolites with Antimicrobial Activities)
Four new secondary metabolites, including one spiro[anthracenone-xanthene] derivative aspergiloxathene A (1), one penicillide analogue, Δ2′-1′-dehydropenicillide (2), and two new phthalide derivatives, 5-methyl-3-methoxyepicoccone (3) and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (4), together with four known compounds, yicathin C (5), dehydropenicillide (6), 3-methoxyepicoccone (7), 4-hydroxy-6-methoxy-5-methylphthalide (8), were identified from the marine-derived fungus Aspergillus sp. IMCASMF180035. Their structures were determined by spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance (NMR) techniques. Compound 1 was identified as the first jointed molecule by xanthene and anthracenone moieties possessing an unprecedented carbon skeleton with spiro-ring system. All compounds were evaluated activities against Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Escherichia coli, Escherichia faecium, Pseudomonas aeruginosa, and Helicobacter pylori. Compound 1 showed significant inhibitory effects against S. aureus and MRSA, with minimum inhibitory concentration (MIC) values of 5.60 and 22.40 µM. Compounds 2 and 6 exhibited potent antibacterial activities against H. pylori, with MIC values of 21.73 and 21.61 µM, respectively. View Full-Text
Keywords: marine-derived fungus; Aspergillus sp.; natural products; anti-Staphylococcus aureus; anti-Helicobacter pylori marine-derived fungus; Aspergillus sp.; natural products; anti-Staphylococcus aureus; anti-Helicobacter pylori
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MDPI and ACS Style

Song, F.; Lin, R.; Yang, N.; Jia, J.; Wei, S.; Han, J.; Li, J.; Bi, H.; Xu, X. Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035. Antibiotics 2021, 10, 377. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10040377

AMA Style

Song F, Lin R, Yang N, Jia J, Wei S, Han J, Li J, Bi H, Xu X. Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035. Antibiotics. 2021; 10(4):377. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10040377

Chicago/Turabian Style

Song, Fuhang, Rui Lin, Na Yang, Jia Jia, Shangzhu Wei, Jiahui Han, Jiangpeng Li, Hongkai Bi, and Xiuli Xu. 2021. "Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035" Antibiotics 10, no. 4: 377. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10040377

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