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Review

Testudines as Sentinels for Monitoring the Dissemination of Antibiotic Resistance in Marine Environments: An Integrative Review

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Centre for Molecular Therapeutics, College of Public Health, Medical and Veterinary Sciences, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD 4811, Australia
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Centre for Sustainable Tropical Fisheries and Aquaculture, Centre for Tropical Bioinformatics and Molecular Biology, College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia
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Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia
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Townsville Water and Waste, Wastewater Operations, Townsville, QLD 4810, Australia
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College of Science, Technology and Engineering, James Cook University, Townsville, QLD 4811, Australia
*
Authors to whom correspondence should be addressed.
Academic Editor: Won-Kyo Jung
Received: 28 May 2021 / Revised: 21 June 2021 / Accepted: 23 June 2021 / Published: 25 June 2021
(This article belongs to the Section Antibiotics Use and Antimicrobial Stewardship)
Dissemination of antibiotic resistance (AR) in marine environments is a global concern with a propensity to affect public health and many ecosystems worldwide. We evaluated the use of sea turtles as sentinel species for monitoring AR in marine environments. In this field, antibiotic-resistant bacteria have been commonly identified by using standard culture and sensitivity tests, leading to an overrepresentation of specific, culturable bacterial classes in the available literature. AR was detected against all major antibiotic classes, but the highest cumulative global frequency of resistance in all represented geographical sites was against the beta-lactam class by a two-fold difference compared to all other antibiotics. Wastewater facilities and turtle rehabilitation centres were associated with higher incidences of multidrug-resistant bacteria (MDRB) accounting for an average of 58% and 49% of resistant isolates, respectively. Furthermore, a relatively similar prevalence of MDRB was seen in all studied locations. These data suggest that anthropogenically driven selection pressures for the development of AR in sea turtles and marine environments are relatively similar worldwide. There is a need, however, to establish direct demonstrable associations between AR in sea turtles in their respective marine environments with wastewater facilities and other anthropogenic activities worldwide. View Full-Text
Keywords: anthropogenic pollution; antimicrobial pollution; multidrug-resistant bacteria; horizontal gene transfer; wastewater treatment plants; turtle rehabilitation centres anthropogenic pollution; antimicrobial pollution; multidrug-resistant bacteria; horizontal gene transfer; wastewater treatment plants; turtle rehabilitation centres
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MDPI and ACS Style

Drane, K.; Huerlimann, R.; Power, M.; Whelan, A.; Ariel, E.; Sheehan, M.; Kinobe, R. Testudines as Sentinels for Monitoring the Dissemination of Antibiotic Resistance in Marine Environments: An Integrative Review. Antibiotics 2021, 10, 775. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10070775

AMA Style

Drane K, Huerlimann R, Power M, Whelan A, Ariel E, Sheehan M, Kinobe R. Testudines as Sentinels for Monitoring the Dissemination of Antibiotic Resistance in Marine Environments: An Integrative Review. Antibiotics. 2021; 10(7):775. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10070775

Chicago/Turabian Style

Drane, Kezia, Roger Huerlimann, Michelle Power, Anna Whelan, Ellen Ariel, Madoc Sheehan, and Robert Kinobe. 2021. "Testudines as Sentinels for Monitoring the Dissemination of Antibiotic Resistance in Marine Environments: An Integrative Review" Antibiotics 10, no. 7: 775. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10070775

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