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Article

Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin

1
Department of Pharmaceutical Services, University of New Mexico Hospital, 2211 Lomas Blvd NE, Albuquerque, NM 87106, USA
2
College of Pharmacy, University of New Mexico Health Sciences Center, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131, USA
3
Division of Infectious Diseases, Department of Internal Medicine, 1 University of New Mexico, Albuquerque, NM 87131, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Jerod Nagel and Angela Huang
Received: 11 June 2015 / Accepted: 20 July 2015 / Published: 24 July 2015
(This article belongs to the Special Issue Antimicrobial Stewardship)
Infectious Diseases specialists have used high-dose daptomycin (≥6 mg/kg/day) in select patients with difficult to treat methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) infections to optimize outcomes. Antimicrobial stewardship programs enforce antimicrobial formulary restrictions; however, interventions specifically aimed at Infectious Disease specialists can be particularly challenging. The purpose of this study was to create a high-dose daptomycin algorithm for Infectious Disease specialists that are consistent with best-practices. Daptomycin prescribing habits pre- and post-daptomycin algorithm implementation were evaluated using a quasi-experimental study design. Patients were included if ≥18 years of age and received daptomycin for ≥48 h. Patients were excluded if daptomycin was initiated on an outpatient setting. During the 12-month pre-intervention phase, 112 patients were included, with 73 patients in the 12-month post-intervention phase. A statistically significant decrease in the mean daptomycin dose from 9.01 mg/kg to 7.51 mg/kg (p < 0.005) was observed, resulting in an annual drug cost-savings of over $75,000 without adversely affecting readmission rates due to infection. Creation of a daptomycin algorithm with consideration of pathogen, disease state, and prior treatment, is an effective means of influencing prescribing habits of Infectious Disease specialists. View Full-Text
Keywords: antimicrobial stewardship; daptomycin; infectious diseases antimicrobial stewardship; daptomycin; infectious diseases
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MDPI and ACS Style

Ross, J.L.; Rankin, S.; Marshik, P.; Mercier, R.-C.; Brett, M.; Walraven, C.J. Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin. Antibiotics 2015, 4, 309-320. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics4030309

AMA Style

Ross JL, Rankin S, Marshik P, Mercier R-C, Brett M, Walraven CJ. Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin. Antibiotics. 2015; 4(3):309-320. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics4030309

Chicago/Turabian Style

Ross, Jennifer L., Shannon Rankin, Patricia Marshik, Renée-Claude Mercier, Meghan Brett, and Carla J. Walraven. 2015. "Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin" Antibiotics 4, no. 3: 309-320. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics4030309

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