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Open AccessReview

Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins

1
Institut de Biologie Structurale (IBS), University Grenoble Alpes, CEA, CNRS, Grenoble 38044, France
2
Invasive Bacterial Infection and National Reference Center for Meningococci, Institut Pasteur, Paris 75015, France
*
Author to whom correspondence should be addressed.
Academic Editor: Waldemar Vollmer
Received: 20 July 2016 / Revised: 22 September 2016 / Accepted: 23 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Bacterial Cell Wall as Antimicrobial Target)
Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that cause a variety of life-threatening systemic and local infections, such as meningitis or gonorrhoea. The treatment of such infection is becoming more difficult due to antibiotic resistance. The focus of this review is on the mechanism of reduced susceptibility to penicillin and other β-lactams due to the modification of chromosomally encoded penicillin-binding proteins (PBP), in particular PBP2 encoded by the penA gene. The variety of penA alleles and resulting variant PBP2 enzymes is described and the important amino acid substitutions are presented and discussed in a structural context. View Full-Text
Keywords: Neisseria meningitidis; Neisseria gonorrhoeae; β-lactam resistance; penicillin-binding proteins Neisseria meningitidis; Neisseria gonorrhoeae; β-lactam resistance; penicillin-binding proteins
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MDPI and ACS Style

Zapun, A.; Morlot, C.; Taha, M.-K. Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins. Antibiotics 2016, 5, 35. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics5040035

AMA Style

Zapun A, Morlot C, Taha M-K. Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins. Antibiotics. 2016; 5(4):35. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics5040035

Chicago/Turabian Style

Zapun, André; Morlot, Cécile; Taha, Muhamed-Kheir. 2016. "Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins" Antibiotics 5, no. 4: 35. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics5040035

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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