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Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review

1
Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
2
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Old Road Campus, Roosevelt Drive, Oxford OX3 7BN, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Mary Barton
Received: 9 September 2016 / Revised: 19 October 2016 / Accepted: 20 October 2016 / Published: 2 November 2016
(This article belongs to the Special Issue Antibiotics in Animal Health)
Southeast Asia is an area of great economic dynamism. In recent years, it has experienced a rapid rise in the levels of animal product production and consumption. The region is considered to be a hotspot for infectious diseases and antimicrobial resistance (AMR). We reviewed English-language peer-reviewed publications related to antimicrobial usage (AMU) and AMR in animal production, as well as antimicrobial residues in meat and fish from 2000 to 2016, in the region. There is a paucity of data from most countries and for most bacterial pathogens. Most of the published work relates to non-typhoidal Salmonella (NTS), Escherichia coli (E. coli), and Campylobacter spp. (mainly from Vietnam and Thailand), Enterococcus spp. (Malaysia), and methicillin-resistant Staphylococcus aureus (MRSA) (Thailand). However, most studies used the disk diffusion method for antimicrobial susceptibility testing; breakpoints were interpreted using Clinical Standard Laboratory Institute (CSLI) guidelines. Statistical models integrating data from publications on AMR in NTS and E. coli studies show a higher overall prevalence of AMR in pig isolates, and an increase in levels of AMR over the years. AMU studies (mostly from Vietnam) indicate very high usage levels of most types of antimicrobials, including beta-lactams, aminoglycosides, macrolides, and quinolones. This review summarizes information about genetic determinants of resistance, most of which are transferrable (mostly plasmids and integrons). The data in this review provide a benchmark to help focus research and policies on AMU and AMR in the region. View Full-Text
Keywords: antimicrobial resistance; antimicrobial consumption; antimicrobial residues; animal production; farms; chickens; pigs; Salmonella; E. coli antimicrobial resistance; antimicrobial consumption; antimicrobial residues; animal production; farms; chickens; pigs; Salmonella; E. coli
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MDPI and ACS Style

Nhung, N.T.; Cuong, N.V.; Thwaites, G.; Carrique-Mas, J. Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review. Antibiotics 2016, 5, 37. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics5040037

AMA Style

Nhung NT, Cuong NV, Thwaites G, Carrique-Mas J. Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review. Antibiotics. 2016; 5(4):37. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics5040037

Chicago/Turabian Style

Nhung, Nguyen T.; Cuong, Nguyen V.; Thwaites, Guy; Carrique-Mas, Juan. 2016. "Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review" Antibiotics 5, no. 4: 37. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics5040037

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