Next Article in Journal
Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data
Next Article in Special Issue
Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review
Previous Article in Journal
Specificity in the Susceptibilities of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus Clinical Isolates to Six Metal Antimicrobials
Previous Article in Special Issue
Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA
Open AccessReview

The Continuing Threat of Methicillin-Resistant Staphylococcus aureus

Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary
Received: 27 March 2019 / Revised: 28 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Staphylococci Antimicrobial Resistance)
Staphylococcus aureus has been an exceptionally successful pathogen, which is still relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be a causative agent in a plethora of infections, owing to its abundance (in the environment and in the normal flora) and the variety of virulence factors that it possesses. Methicillin-resistant S. aureus (MRSA) strains—first described in 1961—are characterized by an altered penicillin-binding protein (PBP2a/c) and resistance to all penicillins, cephalosporins, and carbapenems, which makes the β-lactam armamentarium clinically ineffective. The acquisition of additional resistance determinants further complicates their eradication; therefore, MRSA can be considered as the first representative of multidrug-resistant bacteria. Based on 230 references, the aim of this review is to recap the history, the emergence, and clinical features of various MRSA infections (hospital-, community-, and livestock-associated), and to summarize the current advances regarding MRSA screening, typing, and therapeutic options (including lipoglycopeptides, oxazolidinones, anti-MRSA cephalosporins, novel pleuromutilin-, tetracycline- and quinolone-derivatives, daptomycin, fusidic acid, in addition to drug candidates in the development phase), both for an audience of clinical microbiologists and infectious disease specialists. View Full-Text
Keywords: Staphylococcus; MRSA; SSCmec; colonization; typing; lipoglycopeptides; oxazolidinones; ceftaroline; daptomycin; pleuromutilin Staphylococcus; MRSA; SSCmec; colonization; typing; lipoglycopeptides; oxazolidinones; ceftaroline; daptomycin; pleuromutilin
Show Figures

Graphical abstract

MDPI and ACS Style

Gajdács, M. The Continuing Threat of Methicillin-Resistant Staphylococcus aureus. Antibiotics 2019, 8, 52. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8020052

AMA Style

Gajdács M. The Continuing Threat of Methicillin-Resistant Staphylococcus aureus. Antibiotics. 2019; 8(2):52. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8020052

Chicago/Turabian Style

Gajdács, Márió. 2019. "The Continuing Threat of Methicillin-Resistant Staphylococcus aureus" Antibiotics 8, no. 2: 52. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8020052

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop