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Phenotypic and Genotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Related to Persistent Endovascular Infection
Article

Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users

1
Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS 66044, USA
2
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66044, USA
*
Author to whom correspondence should be addressed.
Received: 9 May 2019 / Revised: 31 May 2019 / Accepted: 12 June 2019 / Published: 17 June 2019
(This article belongs to the Special Issue Staphylococci Antimicrobial Resistance)
In this study, we develop and present a deterministic model for the transmission dynamics of methicillin-resistant staphylococcus aureus (MRSA) among injection drug users. The model consists of non-injection drug users as well as low-and high-risk injection drug users (IDUs). The model further incorporates the movement of these individuals between large metro, suburban and rural areas. The model parameters were estimated by fitting the model to the 2008–2013 disease prevalence data for non-IDUs obtained from the Agency for Healthcare and Research and Quality (AHRQ), as well as the 2009–2013 Census Bureau data for the number of individuals migrating between three different counties in Kansas. Sensitivity analysis was implemented to determine the parameters with the most significant impact on the total number of infected individuals; the transmission probability, recovery rates, and positive behavioral change parameter for the subgroup have the most significant effect on the number of infected individuals. Furthermore, the sensitivity of the parameters in the different areas was the same when the areas are disconnected. When the areas are connected, the parameters in large-metro areas were the most sensitive, and the rural areas were least sensitive. The result shows that to effectively control the disease across the large metro, suburban and rural areas, it is best to focus on controlling both behavior and disease in the large metro area as this has a trickle-down effect to the other places. However, controlling behavior and disease at the same time in all the areas will lead to the elimination of the disease. View Full-Text
Keywords: MRSA; injection drug users; mobility; sensitivity analysis; control strategies MRSA; injection drug users; mobility; sensitivity analysis; control strategies
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MDPI and ACS Style

Agusto, F.B.; Kim, S. Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users. Antibiotics 2019, 8, 81. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8020081

AMA Style

Agusto FB, Kim S. Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users. Antibiotics. 2019; 8(2):81. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8020081

Chicago/Turabian Style

Agusto, Folashade B., and Soyeon Kim. 2019. "Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users" Antibiotics 8, no. 2: 81. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics8020081

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